NiTi laser textured implants with improved in vivo osseointegration:An experimental study in rats

M.M.Costa ¹A.Miranda ²F.Bartolomeu ¹0.Carvalho ¹S.Matos ³G.Miranda ⁴F.S.Silva¹

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作者信息

1. Center for MicroElectroMechanical Systems(CMEMS-UMinho),University of Minho,Campus de Azurém,Guimaraes 4800-058,Portugal
2. Life and Health Sciences Research Institute(ICVS),School of Medicine,University of Minho,Campus de Gualtar,Braga 4710-057,Portugal;ICVS/3B's-PT Government Associate Laboratory,Braga/Guimaraes,Portugal
3. Center for Innovation and Research in Oral Sciences(CIROS),Faculty of Medicine,University of Coimbra,FMUC,Portugal
4. CICECO,Aveiro Institute of Materials,Department of Materials and Ceramic Engineering,University of Aveiro,Aveiro 3810-193,Portugal
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Abstract

Laser surface texturing is a versatile approach for manufacturing implants with suitable surfaces for os-seointegration.This work explores the use of laser to fabricate NiTi textured implants,testing two dif-ferent groove-based designs.Their performance was evaluated in vivo through implantation in Sprague Dawley rats'femur,being then analyzed after 4 and 12 weeks of implantation.Push-out experiments and histological characterization allowed to assess bone-implant bond and osseointegration and to compare the laser textured solutions with non-textured NiTi.Histology showed that,at 4 weeks of implantation,mainly immature woven bone was present whilst at 12 weeks a more mature bone had developed.Con-sidering the largest implantation time(12 weeks),results showed extraction forces considerably higher for textured implants(G2 and G3).Moreover,when comparing G2 and G3,it was found that G2(having the highest textured surface area)displayed the maximum extraction force among all groups,with an increase of 212％when compared to non-textured implants(G1).These results prove that the design and manufacturing technology are effective to promote an im-proved bone-implant bond,aiming the development of orthopedic implants.

Key words

NiTi/Laser surface texturing/In vivo studies/Osseointegration/Implants

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基金项目

FCT through the grants(SFRH/BD/140191/2018)

project (Add2MechBio)(PTDC/EME-EME/1442/2020)

project (Funlmp)(PTDC/EME-EME/30498/2017)

National funds,through the Foundation for Science and Technology(FCT)(U1DB/50026/2020)

National funds,through the Foundation for Science and Technology(FCT)(UIDP/50026/2020)

FCT national funds,under the national support to Research and Development units grant,through the reference projects(UIDB/04436/2020)

FCT national funds,under the national support to Research and Development units grant,through the reference projects(UIDP/04436/2020)

出版年

2022

材料科学技术(英文版)

中国金属学会中国材料研究学会中国科学院金属研究所

材料科学技术(英文版)

CSTPCDCSCDSCI

影响因子：0.657

ISSN：1005-0302

参考文献量41

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