首页|Wireless electrical stimulation generated by piezoelectric nanomaterial promotes the dental pulp regeneration via regulating mitochondrial Ca2+/PKA signaling pathway

Wireless electrical stimulation generated by piezoelectric nanomaterial promotes the dental pulp regeneration via regulating mitochondrial Ca2+/PKA signaling pathway

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The induction of dental pulp stem cells(DPSCs)into odontogenic differentiation is a cutting-edge method of dental pulp regeneration treatment.However,it remains a challenge to develop biomaterials and ther-apies that can induce odontogenic differentiation.Here,we propose a wireless electrical stimulation strat-egy to induce DPSCs odontogenic differentiation via K0.5Na0.5NbC3 piezoelectric nanoparticles(KNN)and polarized KNN(PKNN),which can be endocytosed by DPSCs.In vitro,several odontogenic differentiation indexes were also increased in DPSCs treated with KNN and PKNN,and the increase was more obvious in the PKNN group.Intracellular wireless electrical field promoted mitochondrial calcium concentration via mitochondrial calcium unidirectional transporter(MCU),increased the production of adenosine triphos-phate(ATP),and induced odontogenic differentiation through the activation of the cAMP-PKA signaling pathway.In vivo,dental pulp-like tissue was induced by electrical stimulation wirelessly with KNN and PKNN,which was more clinically friendly compared with the wired device,and the induction was more obvious in the PKNN group consistent with in vitro experiments.In conclusion,this work demonstrates the potential of PKNN as an effective stimulus that can induce odontogenic differentiation of DPSCs and be applied to dental pulp regeneration treatment.

Piezoelectric nanoparticlesDental pulp stem cellsOdontogenic differentiation

Jianmao Zheng、Jiyuan Zuo、Cairong Xiao、Qining Guo、Xiaobin Fu、Chengyun Ning、Peng Yu

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Guangdong Provincial Key Laboratory of Stomatology,Hospital of Stomatology,Sun Yat-Sen University,Guangzhou 510080,China

School of Materials Science and Engineering,National Engineering Research Center for Tissue Restoration and Reconstruction,South China University of Technology,Guangzhou 510641,China

Guangdong Basic and Applied Basic Research FoundationGuangdong Basic and Applied Basic Research Foundation国家自然科学基金国家自然科学基金Medical Scientific Research Foundation of Guangdong Province of China

2022A15150112662019A15150112895207212781700950A2022322

2024

10.1016/j.jmst.2023.04.077

材料科学技术(英文版)
中国金属学会 中国材料研究学会 中国科学院金属研究所

材料科学技术(英文版)

CSTPCD
影响因子：0.657
ISSN：1005-0302
年,卷(期)：2024.168(1)
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