首页|Enhanced antibacterial activity,corrosion resistance and endothelialization potential of Ti-5Cu alloy by oxygen and nitrogen plasma-based surface modification
Enhanced antibacterial activity,corrosion resistance and endothelialization potential of Ti-5Cu alloy by oxygen and nitrogen plasma-based surface modification
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Antibacterial Ti-5Cu alloy is a promising substitute material for Ti-made cardiovascular implants,so its surface engineering is crucial to expediting clinical implementation.Given the antibacterial and cardiovas-cular biological benefits of Cu2+and titanium-nitride-oxide(TiNxOy)coatings,a Cu2O/CuO-TiNxOy coating with upregulated Cu2+release was successfully deposited on Ti-5Cu alloy for the first time using oxygen and nitrogen plasma-based surface modification.The superhydrophilic and nanostructured Cu2O/CuO-TiNxOy coating had a dense structure and was well bonded to the substrate,resulting in enhanced cor-rosion resistance,while CuO/Cu2O in the coating released Cu2+faster than Ti2Cu phase in the matrix.More gratifying,the coating demonstrated perfect antibacterial properties(R＞99.9％against S.aureus),owing primarily to direct contact sterilization of Cu2O/CuO.The most encouraging phenomenon was that the coating dramatically accelerated HUVEC adhesion(1.4 times),proliferation(RGR:106％-116％),and particularly migration(RMR:158％-247％)compared with the control Ti.The coating extract also signifi-cantly stimulated in vitro angiogenesis capacity.The rapid endothelialization for Cu2O/CuO-TiNxOy coating was attributed to the surface nanostructure and Cu2+/NO2-release,which upregulated the angiogenesis-related gene expression of HIF-1α,VEGF,and eNOS to increase VEGF secretion and NO production.All of the findings indicated that the Cu2O/CuO-TiNxOy coating could enhance the corrosion resistance,an-tibacterial properties,and endothelialization potential of Ti-Cu alloy,displaying great clinical potential in cardiovascular applications.
Key Lab.for Anisotropy and Texture of Materials,Education Ministry of China,School of Materials Science and Engineering,Northeastern University,Shenyang 110819,China
Laboratory of Bone Tissue Engineering,Beijing Laboratory of Biomedical Materials,National Center for Orthopaedics,Beijing Research Institute of Traumatology and Orthopaedics,Beijing Jishuitan Hospital,Beijing 100035,China
Research Center for Metallic Wires,Northeastern University.Shenyang 110819,China
国家重点研发计划Research Program国家自然科学基金Beijing Municipal Health CommissionBeijing Municipal Health CommissionBeijing Municipal Health Commission
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