首页|Extrusion-based 3D-printed"rolled-up"composite scaffolds with hierarchical pore structure for bone growth and repair
Extrusion-based 3D-printed"rolled-up"composite scaffolds with hierarchical pore structure for bone growth and repair
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Three-dimensional(3D)bioprinting,specifically direct ink writing(DIW)capable of printing biologically active substances such as growth factors or drugs under low-temperature conditions,is an emerging di-rection in bone tissue engineering.However,limited by the bio-ink mobility and the poor resolution of this printing technology,the lateral pores of current crisscross-stacked scaffolds printed through DIW tend to clog and are inimical to bone growth.Therefore,it is critical to develop DIW printed biologi-cal scaffold structure with high mechanical strength,porosity,and biocompatibility performance.Herein,patterned polylactic acid(PLA)/polycaprolactone(PCL)/nano-hydroxyapatite(n-HA)based scaffold was printed through DIW technological and rolled-up for properties characterization,cytocompatibility test,and bone repair experiment.The result not only shows that the hexagonal patterned scaffolds are me-chanically strong with porosity,but also demonstrated that the hierarchical pore structure formed during rolled-up has the potential to address the clogging problem and stimulates bone growth and repair.
Direct ink writing(DIW)Bone repair scaffold,Micro-CTBio composites
Yufan Li、Li Chen、Yijing Stehle、Mingyue Lin、Chenxin Wang、Rui Zhang、Min Huang、Yubao Li、Qin Zou
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Research Center for Nano Biomaterials,Analytical & Testing Center,Sichuan University,Chengdu 610064,China
Department of mechanical engineering,Union College,807 Union St.,Schenectady,NY 12308,USA
Sichuan Institute of Atomic Energy,Chengdu 610101,China
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China NSFC projectKey Science and Technology Special Project of Sichuan ProvinceInnovation and Reform Project of Postgraduate Education of Sichuan University in 2021Experimental Technology Research Project of Sichuan University
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