Effect of mechanical stresses on degradation behavior of high-purity magnesium in bone environments

Yan Yao ¹Jie Xia ¹Lizhen Wang ¹Yuanming Gao ¹Xili Ding ¹Chao Wang ¹Yubo Fan¹

扫码查看

作者信息

1. Key Laboratory of Biomechanics and Mechanobiology(Beihang University),Ministry of Education,Beijing Advanced Innovation Center for Biomedical Engineering,School of Biological Science and Medical Engineering,School of Engineering Medicine,Beihang University,Beijing 100083,China
折叠

Abstract

High-purity(HP)magnesium(Mg)has emerged as a promising biomaterial for supporting functional bone tissue.Our previous study found that mechanical stresses and the surrounding fibrotic tissue(subcuta-neous)both play crucial roles in the degradation of HP Mg.However,due to challenges in the degradation and regeneration process in vivo,it remains unclear how stress affects HP Mg degradation in bone en-vironments,limiting its further application.In this study,novel loading devices were designed and the effects of tensile and compressive stresses on HP Mg degradation in vivo and in vitro bone environments were quantitatively analyzed.In addition,bone osteointegration around HP Mg was explored preliminar-ily.Tensile stress increases the degradation rate of HP Mg in vivo and in vitro.HP Mg degradation in vivo is more sensitive to stress factors than in vitro,but the sensitivity decreases with corrosion time.The volume loss rate of HP Mg is multilinear with the applied stress and degradation time.The volume of bone tissue surrounding HP Mg is larger in the no-stress group compared to the stressed groups,which is more pronounced with increasing implantation time.These results provide valuable insights for optimiz-ing the design of HP Mg-based implants considering load conditions.This will help to achieve a balance between the degradation rate of the implant and the regeneration rate of the surrounding bone.

Key words

High-purity magnesium/Quantitative stresses/Degradation/Bone environments/In vivo and in vitro

引用本文复制引用

基金项目

National Natural Science Foundation of China(T2288101)

National Natural Science Foundation of China(12172034)

National Natural Science Foundation of China(U20A20390)

National Natural Science Foundation of China(11827803)

National Natural Science Foundation of China(12202036)

Beijing Municipal Natural Science Foundation(7212205)

111 Project(B13003)

Fundamental Research Funds for the Central Universities()

出版年

2024

材料科学技术(英文版)

中国金属学会中国材料研究学会中国科学院金属研究所

材料科学技术(英文版)

CSTPCDCSCD

影响因子：0.657

ISSN：1005-0302

参考文献量57

段落导航