首页|Medical titanium surface-modified coatings with antibacterial and anti-adhesive properties for the prevention of implant-associated infections

Medical titanium surface-modified coatings with antibacterial and anti-adhesive properties for the prevention of implant-associated infections

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
Implant-associated infections(IAIs)caused by drug-resistant bacteria remain a critical factor in the fail-ure of implant procedures.Therefore,it is urgent to develop an effective anti-infection coating for im-plant surface modification to prevent IAIs.Herein,an antibacterial and anti-adhesive coating(CMP-Ti)constructed on the surface of titanium implants is reported,formed by the nanomaterial CeO2@Mn3O4 NRs(CM NRs)with antibacterial activity and the superhydrophilic polymer polyethylene glycol(PEG).The nanocatalyst CM NRs on the surface of CMP-Ti induce ferroptosis-like death of bacteria by catalyzing the production of hydroxyl radical(·OH)and singlet oxygen(1O2)and the consumption of glutathione(GSH).The superhydrophilic coating of CMP-Ti can effectively prevent adherence of drug-resistant bac-teria and avoid biofilm formation.By combining the"active offense"antibacterial mechanism with the"passive defense"anti-adhesion mechanism,CMP-Ti can kill bacteria and inhibit biofilm formation.The results of in vivo studies showed that CMP-Ti effectively prevented implant-associated infections caused by Methicillin-resistant Staphylococcus aureus(MRSA),thus promoting tissue repair and osseointegra-tion.Therefore,this multifunctional coating combining"active offense"and"passive defense"provides a promising way to prevent IAIs caused by drug-resistant bacteria and to promote tissue repair in the future.

Medical titaniumAntibacterial coatingsDrug-resistant bacteriaBiofilm inhibitionFerroptosis-like death

Dongliang Huo、Fengqian Wang、Fengjuan Yang、Tongyao Lin、Qing Zhong、Sui-Ping Deng、Jingxian Zhang、Shaozao Tan、Langhuan Huang

展开 >

Guangdong Engineering & Technology Research Centre of Graphene-like Materials and Products,Department of Chemistry,College of Chemistry and Materials Science,Jinan University,Guangzhou 510632,China

Natural Science Key Foundation of Guangdong ProvinceNational Natural Science Foundation of ChinaInnovation Team Project of Foshan Cityopen experimental project by GETRC of Graphenelike Materials and Products

2019B151512005651872124FSOAA-KJ919-4402-0086GETRCGL-202207

2024

10.1016/j.jmst.2023.09.016

材料科学技术(英文版)
中国金属学会 中国材料研究学会 中国科学院金属研究所

材料科学技术(英文版)

CSTPCD
影响因子：0.657
ISSN：1005-0302
年,卷(期)：2024.179(12)
  • 66