材料科学技术(英文版)2024，Vol.179Issue(12) ：224-239.DOI:10.1016/j.jmst.2023.09.019

Optimization of the in vitro biodegradability,cytocompatibility,and wear resistance of the AZ31B alloy by micro-arc oxidation coatings doped with zinc phosphate

Chao Yang Suihan Cui Ricky K.Y.Fu Liyuan Sheng Min Wen Daokui Xu Ying Zhao Yufeng Zheng Paul K.Chu Zhongzhen Wu
材料科学技术(英文版)2024，Vol.179Issue(12) ：224-239.DOI:10.1016/j.jmst.2023.09.019
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Optimization of the in vitro biodegradability,cytocompatibility,and wear resistance of the AZ31B alloy by micro-arc oxidation coatings doped with zinc phosphate

Chao Yang 1Suihan Cui 2Ricky K.Y.Fu 3Liyuan Sheng 4Min Wen 5Daokui Xu 6Ying Zhao 7Yufeng Zheng 5Paul K.Chu 3Zhongzhen Wu8
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作者信息

  • 1. School of Advanced Materials,Peking University Shenzhen Graduate School,Shenzhen 518055,China;National Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite,Shanghai Jiao Tong University,Shanghai 200240,China
  • 2. School of Advanced Materials,Peking University Shenzhen Graduate School,Shenzhen 518055,China;Department of Physics,Department of Materials Science & Engineering,and Department of Biomedical Engineering,City University of Hong Kong,Tat Chee Avenue,Kowloon,Hong Kong 999077,China
  • 3. Department of Physics,Department of Materials Science & Engineering,and Department of Biomedical Engineering,City University of Hong Kong,Tat Chee Avenue,Kowloon,Hong Kong 999077,China
  • 4. Shenzhen Institute,Peking University,Shenzhen 518057,China;PKU-HKUST Shenzhen-Hong Kong Institution,Shenzhen 518057,China
  • 5. Shenzhen Institute,Peking University,Shenzhen 518057,China
  • 6. Key Laboratory of Nuclear Materials and Safety Assessment,Institute of Metal Research,Chinese Academy of Sciences,Shenyang 110016,China
  • 7. Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China
  • 8. School of Advanced Materials,Peking University Shenzhen Graduate School,Shenzhen 518055,China
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Abstract

As implanted bone fixation materials,magnesium(Mg)alloys have significant advantages because the density and elastic modulus are closest to those of the human bone and they can bio-degrade in the physiological environment.However,Mg alloys degrade too rapidly and uncontrollably thus hampering clinical adoption.In this study,a highly corrosion-resistant zinc-phosphate-doped micro-arc oxidation(MAO)coating is prepared on the AZ31B alloy,and the degradation process is assessed in vitro.With increasing zinc phosphate concentrations,both the corrosion potentials and charge transfer resistance of the AZ31B alloy coated with MAO coatings increase gradually,while the corrosion current densities di-minish gradually.Immersion tests in the simulated body fluid(SBF)reveal that the increased zinc phos-phate concentration in MAO coating decreases the degradation rate,consequently reducing the release rates of Mg2+and OH-in the physiological micro-environment,which obtains the lowest weight loss of only 5.22％after immersion for 56 days.Effective regulation of degradation provides a weak alkaline environment that is suitable for long-term cell growth and subsequent promotion of bone proliferation,differentiation,mineralization,and cytocompatibility.In addition,the zinc-phosphate-doped MAO coat-ings show an improved wear resistance as manifested by a wear rate of only 3.81 x 10-5 mm3 N-1 m-'.The results reveal a suitable strategy to improve the properties of biodegradable Mg alloys to balance tissue healing with mechanical degradation.

Key words

Mg alloys/MAO coatings/Degradation regulation/Cytocompatibility/Wear resistance

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基金项目

Shenzhen-Hong Kong Research and Development Fund(SGDX20201103095406024)

2022 Shenzhen Sustainable Supporting Funds for Colleges and Universities(20220810143642004)

Shenzhen Basic Research Project(JCYJ20200109144608205)

Shenzhen Basic Research Project(JCYJ20210324120001003)

Guangdong Basic and Applied Basic Research Foundation(2020A1515011301)

Guangdong Basic and Applied Basic Research Foundation(2021A1515012246)

Peking University Shenzhen Graduate School Research Startup Fund of Introducing Talent(1270110273)

Shenzhen Postdoctoral Research Fund Project after Outbound(2129933651)

China Postdoctoral Science Foundation(2023M730032)

City University of Hong Kong Strategic Research Grants(SRG)(7005505)

City University of Hong Kong Donation Research Grants(9220061)

City University of Hong Kong Donation Research Grants(DON-RMG 9229021)

Guangdong-Hong Kong Technology Cooperation Funding Scheme(TCFS)(GHP/085/18SZ)

Shenzhen-Hong Kong Technology Cooperation Funding Scheme(TCFS)(GHP/149/20SZ)

Shenzhen-Hong Kong Technology Cooperation Funding Scheme(TCFS)(CityU 9440296)

IER Foundation(IERF2020001)

IER Foundation(IERF202102)

出版年

2024
材料科学技术(英文版)
中国金属学会 中国材料研究学会 中国科学院金属研究所

材料科学技术(英文版)

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影响因子：0.657
ISSN：1005-0302
参考文献量57
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