Optimization of the in vitro biodegradability,cytocompatibility,and wear resistance of the AZ31B alloy by micro-arc oxidation coatings doped with zinc phosphate

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外文摘要：As implanted bone fixation materials,magnesium(Mg)alloys have significant advantages because the density and elastic modulus are closest to those of the human bone and they can bio-degrade in the physiological environment.However,Mg alloys degrade too rapidly and uncontrollably thus hampering clinical adoption.In this study,a highly corrosion-resistant zinc-phosphate-doped micro-arc oxidation(MAO)coating is prepared on the AZ31B alloy,and the degradation process is assessed in vitro.With increasing zinc phosphate concentrations,both the corrosion potentials and charge transfer resistance of the AZ31B alloy coated with MAO coatings increase gradually,while the corrosion current densities di-minish gradually.Immersion tests in the simulated body fluid(SBF)reveal that the increased zinc phos-phate concentration in MAO coating decreases the degradation rate,consequently reducing the release rates of Mg2+and OH-in the physiological micro-environment,which obtains the lowest weight loss of only 5.22％after immersion for 56 days.Effective regulation of degradation provides a weak alkaline environment that is suitable for long-term cell growth and subsequent promotion of bone proliferation,differentiation,mineralization,and cytocompatibility.In addition,the zinc-phosphate-doped MAO coat-ings show an improved wear resistance as manifested by a wear rate of only 3.81 x 10-5 mm3 N-1 m-'.The results reveal a suitable strategy to improve the properties of biodegradable Mg alloys to balance tissue healing with mechanical degradation.

外文关键词：

Mg alloysMAO coatingsDegradation regulationCytocompatibilityWear resistance

作者：

Chao Yang、Suihan Cui、Ricky K.Y.Fu、Liyuan Sheng、Min Wen、Daokui Xu、Ying Zhao、Yufeng Zheng、Paul K.Chu、Zhongzhen Wu

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作者单位：

School of Advanced Materials,Peking University Shenzhen Graduate School,Shenzhen 518055,China

National Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite,Shanghai Jiao Tong University,Shanghai 200240,China

Department of Physics,Department of Materials Science & Engineering,and Department of Biomedical Engineering,City University of Hong Kong,Tat Chee Avenue,Kowloon,Hong Kong 999077,China

Shenzhen Institute,Peking University,Shenzhen 518057,China

PKU-HKUST Shenzhen-Hong Kong Institution,Shenzhen 518057,China

Key Laboratory of Nuclear Materials and Safety Assessment,Institute of Metal Research,Chinese Academy of Sciences,Shenyang 110016,China

Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China

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基金：

Shenzhen-Hong Kong Research and Development Fund2022 Shenzhen Sustainable Supporting Funds for Colleges and UniversitiesShenzhen Basic Research ProjectShenzhen Basic Research ProjectGuangdong Basic and Applied Basic Research FoundationGuangdong Basic and Applied Basic Research FoundationPeking University Shenzhen Graduate School Research Startup Fund of Introducing TalentShenzhen Postdoctoral Research Fund Project after OutboundChina Postdoctoral Science FoundationCity University of Hong Kong Strategic Research Grants(SRG)City University of Hong Kong Donation Research GrantsCity University of Hong Kong Donation Research GrantsGuangdong-Hong Kong Technology Cooperation Funding Scheme(TCFS)Shenzhen-Hong Kong Technology Cooperation Funding Scheme(TCFS)Shenzhen-Hong Kong Technology Cooperation Funding Scheme(TCFS)IER FoundationIER Foundation

项目编号：

SGDX2020110309540602420220810143642004JCYJ20200109144608205JCYJ202103241200010032020A15150113012021A1515012246127011027321299336512023M73003270055059220061DON-RMG 9229021GHP/085/18SZGHP/149/20SZCityU 9440296IERF2020001IERF202102

出版年：

2024

DOI：

10.1016/j.jmst.2023.09.019

材料科学技术(英文版)

中国金属学会中国材料研究学会中国科学院金属研究所

材料科学技术(英文版)

CSTPCD

影响因子：0.657

ISSN：1005-0302

年,卷(期)：2024.179(12)

参考文献量57