首页|Cross-linked lipoic acid nanoparticles with indole-3-methanol loading for the PTEN-mediated TNBC treatment

Cross-linked lipoic acid nanoparticles with indole-3-methanol loading for the PTEN-mediated TNBC treatment

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We here report a non-gene therapy anti-tumor nanoparticles(I3C@cLANPs)based PTEN by loading indole-3-methanol(I3C)into the cross-linked lipoic acid nanoparticles(cLANPs)for triple-negative breast cancer(TNBC)treatment.I3C is a PTEN-specific natural activator while the poor PTEN-activation effi-ciency impedes its ability to achieve the PTEN-mediated tumor therapy.Due to the structural homology of lipoic acid(LA),the cLANPs hold not only LA-like anticancer activity but also PTEN-activation proper-ties,which would synergistically potentiate the PTEN-activation efficiency.The in vitro and in vivo data showed that PTEN expression in the I3C@cLANPs group was 2.1 and 2.8 times higher than that of I3C,respectively.In antitumor evaluation based on the 4T1 tumor-bearing mice showed a tumor inhibitory rate(TIR)of 78.4％at the I3C usage of 20 mg kg-1,54.5％higher than that of I3C alone and 19.7％higher than that of first-line chemotherapy drug Doxorubicin hydrochloride(DOX).Thus,the I3C@cLANPs could address the low activation efficiency in the PTEN-mediated tumor strategy and avoid the risks of gene therapy,holding a good prospect for TNBC and related cancer treatment.

Triple-negative breast cancerIndole-3-methanolLipoic acidSynergistic therapy

Xiao Xiao、Rong Cui、Chunyan Liao、Shiyong Zhang

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College of Biomedical Engineering and National Engineering Research Center for Biomaterials,Sichuan University,Chengdu 610064,China

国家自然科学基金国家自然科学基金Innovative Research Team Program of Sichuan ProvinceSichuan University postdoctoral interdisciplinary Innovation Fund

22275129219751652021JDTD00152022SCU12106

2024

10.1016/j.jmst.2023.09.026

材料科学技术(英文版)
中国金属学会 中国材料研究学会 中国科学院金属研究所

材料科学技术(英文版)

CSTPCD
影响因子：0.657
ISSN：1005-0302
年,卷(期)：2024.181(14)
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