首页|Chelating ligand-bridged IO-Gd nanoparticles with enhanced contrast performance for dual-mode MRI

Chelating ligand-bridged IO-Gd nanoparticles with enhanced contrast performance for dual-mode MRI

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Magnetic resonance imaging(MRI)is a non-invasive medical imaging technique that has been widely applied in the clinical diagnosis of diseases across various fields.Currently,there is a dearth of high-performance dual-mode contrast agents that provide precise diagnostic information for complex diseases.In this study,iron oxide-gadolinium nanoparticles(IO-Gd NPs)bridged by hydrophilic ligand ethylenedi-amine tetramethylenephosphonic acid(EDTMP)are designed inspired by Solomon-Bloembergen-Morgan(SBM)theory,where T1 and T2 relaxivity increase with a reduction in Gd content.In particular,the NPs with minimum Gd content exhibit excellent dual-mode contrast performance(r1=94.42 mM-1 s-1,r2=343.62 mM-1 s-1).The underlying mechanism is that the bridged EDTMP coordinate limits Gd tum-bling and forces Gd3+to expose itself to the surface of the NPs.This provides more opportunities for water molecules to coordinate with Gd3+and significantly enhances proton relaxivity.Moreover,the hy-drophilicity of the ligand enhances the water dispersion stability of the NPs and increases the exchange rate of water protons near the NPs,further enhancing the dual-mode contrast effect.Finally,the biocom-patibility and in vitro/vivo imaging performances of the IO@EDTMP-Gd NPs are systematically evaluated,and the results demonstrate their potential as dual-mode contrast agents.This study provides a new strategy for developing dual-mode MRI contrast agents that can further improve the accuracy of MRI in the diagnosis of complex diseases.

Magnetic resonance imagingDual-mode contrast agentChelating ligandIron oxideGadolinium

Lili Hao、Haoyang Ding、Xiangchuan Xu、Hongli Mao、Zhongwei Gu

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Research Institute for Biomaterials,Tech Institute for Advanced Materials,Bio-inspired Biomedical Materials & Devices Center,College of Materials Science and Engineering,Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites,Suqian Advanced Materials Industry Technology Innovation Center,Nanjing Tech University,Nanjing 211816,China

NJTech-BARTY Joint Research Center for Innovative Medical Technology,Nanjing 210000,China

National Key R&D Program of ChinaNational Key R&D Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaOutstanding Postdoctoral Program of Jiangsu ProvincePriority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)

2020YFA07108002022YFE012450032271467320713642022ZB367

2024

10.1016/j.jmst.2023.10.030

材料科学技术(英文版)
中国金属学会 中国材料研究学会 中国科学院金属研究所

材料科学技术(英文版)

CSTPCD
影响因子：0.657
ISSN：1005-0302
年,卷(期)：2024.184(17)
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