首页|One-pot synthesis of hydroxyapatite hybrid bioinks for digital light processing 3D printing in bone regeneration

One-pot synthesis of hydroxyapatite hybrid bioinks for digital light processing 3D printing in bone regeneration

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Three-dimensional(3D)bioprinting has revolutionized tissue engineering by enabling precise fabrication with bioinks.Among these techniques,digital light processing(DLP)stands out due to its exceptional resolution,speed,and biocompatibility.However,the progress of DLP is hindered by the limited avail-ability of suitable bioinks.Currently,some studies involve simple mixing of different materials,resulting in bioinks that lack uniformity and photopolymerization characteristics.To address this challenge,we present an innovative one-pot synthesis method for bioinks based on methacrylated gelatin/alginate with hydroxyapatite(HAP).This approach offers significant advantages in terms of efficiency and uniformity.The synthesized bioinks demonstrate excellent printability,stability,and notably enhanced mechanical properties,facilitating optimal in vitro compatibility.Additionally,the HAP-hybrid bioinks printed scaf-folds demonstrated impressive bone repair capabilities in vivo compared with pure organic bioinks.In conclusion,the Gel/Alg/HAP bioinks presented herein offer an innovative solution for DLP bioprinting within the field of bone tissue engineering.Their multifaceted advantages help overcome the limitations of restricted bioink choices,pushing forward the boundaries of bioprinting technology and contributing to the progress of regenerative medicine and tissue engineering.

One-pot strategyHybrid bioinksDIPBone regeneration3D printing

Xiaoxiang Ren、Jian Wang、Yan Wu、Yuan Zhang、Jieyuan Zhang、Long Bai、Jinlong Liu、Guangfeng Li、Peiran Song、Zhongmin Shi、Jiacan Su

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Institute of Translational Medicine,Shanghai University,Shanghai 200444,China

Musculoskeletal Organoid Research Center,Shanghai University,Shanghai 200444,China

School of Medicine,Shanghai University,Shanghai 200444,China

National Center for Orthopaedics,Shanghai Sixth People's Hospital,Shanghai 200233,China

Department of Orthopedic Surgery,Shanghai Sixth People's Hospital,Shanghai 200233,China

Department of Trauma Orthopedics,Zhongye Hospital,Shanghai 200941,China

Department of Orthopedic,Xin Hua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China

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National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaShanghai Sailing Program

82202335822300718217209822YF1414000

2024

10.1016/j.jmst.2024.01.001

材料科学技术(英文版)
中国金属学会 中国材料研究学会 中国科学院金属研究所

材料科学技术(英文版)

CSTPCD
影响因子：0.657
ISSN：1005-0302
年,卷(期)：2024.188(21)
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