首页|Additive manufactured trabecular-like Ti-6Al-4V scaffolds for promoting bone regeneration

Additive manufactured trabecular-like Ti-6Al-4V scaffolds for promoting bone regeneration

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The Voronoi-tessellation method is a promising technique for porous implant design as it mimics the irregular structure of bone trabeculae very well.However,the optimal pore size distribution of Voronoi-based trabecular-like scaffolds(VBTSs)remains unknown.In this study,three VBTSs with different pore size distributions were fabricated by Electron-beam melting(EBM),with a regular cubic scaffold as a con-trol.Compression experiments showed that the elastic modulus of all the fabricated scaffolds was within the range of human bone.The biocompatibility of the porous scaffolds was evaluated by Cell Counting Kit-8,live/dead staining,phalloidin staining,and scanning electron microscope.The effects of scaffolds on osteogenic differentiation were evaluated by alkaline phosphatase(ALP)assay,Alizarin Red S(ARS)assay,and Real-time quantitative polymerase chain reaction(RT-qPCR).In vivo experiments were performed to evaluate the performance of bone regeneration in the scaffolds.The results showed that all scaffolds were nontoxic with good biosafety,and VBTSs were more conducive to promoting cell proliferation,osteogenic differentiation,and bone regeneration within the scaffolds.Among the 596-1044 μm range,the VBTS with an average pore size of 596 µm performed best.This study showed that bone regeneration could be regulated by controlling the porous structure and provided a reference for applying VBTSs in bone implants.

Voronoi-tessellation designAdditive manufacturingBone regenerationPorous structure

Wenbo Yang、Qing Han、Hao Chen、Yongyue Li、Xingchen Guo、Aobo Zhang、Yang Liu、Yifu Sun、Jincheng Wang

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Department of Orthopedics,Second Hospital of Jilin University,Changchun,130022,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Key R&D Program of ChinaDepartment of Science and Technology of Jilin Province,P.R.CDepartment of Science and Technology of Jilin Province,P.R.CDepartment of Science and Technology of Jilin Province,P.R.CDepartment of Science and Technology of Jilin Province,P.R.CDepartment of Science and Technology of Jilin Province,P.R.CDepartment of Science and Technology of Jilin Province,P.R.CDepartment of Science and Technology of Jilin Province,P.R.CDepartment of Science and Technology of Jilin Province,P.R.CDepartment of finance in Jilin provinceJilin Province Development and Reform Commission,P.R.CJilin Province Development and Reform Commission,P.R.CInterdisciplinary Integration and Cultivation Project of Jilin University

82272504820724562018YFB110510020200404202YY20200403086SF20210101321JC20210204104YY20200201453JC20220204119YY202201ZYTS131202020SCZT0372018C0102022C043-5JLUXKJC2020307

2024

10.1016/j.jmst.2023.10.061

材料科学技术(英文版)
中国金属学会 中国材料研究学会 中国科学院金属研究所

材料科学技术(英文版)

CSTPCD
影响因子：0.657
ISSN：1005-0302
年,卷(期)：2024.188(21)
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