材料科学技术(英文版)2024，Vol.188Issue(21) ：116-130.DOI:10.1016/j.jmst.2023.10.061

Additive manufactured trabecular-like Ti-6Al-4V scaffolds for promoting bone regeneration

Wenbo Yang Qing Han Hao Chen Yongyue Li Xingchen Guo Aobo Zhang Yang Liu Yifu Sun Jincheng Wang
材料科学技术(英文版)2024，Vol.188Issue(21) ：116-130.DOI:10.1016/j.jmst.2023.10.061
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  • NSTL
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Additive manufactured trabecular-like Ti-6Al-4V scaffolds for promoting bone regeneration

Wenbo Yang 1Qing Han 1Hao Chen 1Yongyue Li 1Xingchen Guo 1Aobo Zhang 1Yang Liu 1Yifu Sun 1Jincheng Wang1
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作者信息

  • 1. Department of Orthopedics,Second Hospital of Jilin University,Changchun,130022,China
  • 折叠

Abstract

The Voronoi-tessellation method is a promising technique for porous implant design as it mimics the irregular structure of bone trabeculae very well.However,the optimal pore size distribution of Voronoi-based trabecular-like scaffolds(VBTSs)remains unknown.In this study,three VBTSs with different pore size distributions were fabricated by Electron-beam melting(EBM),with a regular cubic scaffold as a con-trol.Compression experiments showed that the elastic modulus of all the fabricated scaffolds was within the range of human bone.The biocompatibility of the porous scaffolds was evaluated by Cell Counting Kit-8,live/dead staining,phalloidin staining,and scanning electron microscope.The effects of scaffolds on osteogenic differentiation were evaluated by alkaline phosphatase(ALP)assay,Alizarin Red S(ARS)assay,and Real-time quantitative polymerase chain reaction(RT-qPCR).In vivo experiments were performed to evaluate the performance of bone regeneration in the scaffolds.The results showed that all scaffolds were nontoxic with good biosafety,and VBTSs were more conducive to promoting cell proliferation,osteogenic differentiation,and bone regeneration within the scaffolds.Among the 596-1044 μm range,the VBTS with an average pore size of 596 µm performed best.This study showed that bone regeneration could be regulated by controlling the porous structure and provided a reference for applying VBTSs in bone implants.

Key words

Voronoi-tessellation design/Additive manufacturing/Bone regeneration/Porous structure

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基金项目

National Natural Science Foundation of China(82272504)

National Natural Science Foundation of China(82072456)

National Key R&D Program of China(2018YFB1105100)

Department of Science and Technology of Jilin Province,P.R.C(20200404202YY)

Department of Science and Technology of Jilin Province,P.R.C(20200403086SF)

Department of Science and Technology of Jilin Province,P.R.C(20210101321JC)

Department of Science and Technology of Jilin Province,P.R.C(20210204104YY)

Department of Science and Technology of Jilin Province,P.R.C(20200201453JC)

Department of Science and Technology of Jilin Province,P.R.C(20220204119YY)

Department of Science and Technology of Jilin Province,P.R.C(202201ZYTS131)

Department of Science and Technology of Jilin Province,P.R.C(20)

Department of finance in Jilin province(2020SCZT037)

Jilin Province Development and Reform Commission,P.R.C(2018C010)

Jilin Province Development and Reform Commission,P.R.C(2022C043-5)

Interdisciplinary Integration and Cultivation Project of Jilin University(JLUXKJC2020307)

出版年

2024
材料科学技术(英文版)
中国金属学会 中国材料研究学会 中国科学院金属研究所

材料科学技术(英文版)

CSTPCD
影响因子：0.657
ISSN：1005-0302
被引量1
参考文献量64
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