首页|Nature-skin-derived multi-responsive e-skin as on-demand drug-delivery system facilitated melanoma postoperative therapy

Nature-skin-derived multi-responsive e-skin as on-demand drug-delivery system facilitated melanoma postoperative therapy

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An ideal strategy for integrated melanoma treatment involves the pursuit of multifunctional biomaterials that possess adjuvant therapy functions,enabling full-scale postoperative relapse prevention,wound heal-ing,and real-time postoperative surveillance.The simulation of electronic skin(e-skin),which emulates the mechanical properties and functions of natural skin,holds significant potential for broad biomedi-cal applications.Herein,a novel multi-responsive controlled-release e-skin(PADM-MX-Ag-Si@Dox)was developed using natural porcine dermal matrix,MXene nanosheets,silver nanowires(AgNWs),and mesoporous hollow silica microspheres(TSOHSiO2@Dox)for drug-loading.The resulting e-skin exhibited temperature-,pH-,and electric-responsiveness due to the incorporation of TSOHSiO2@Dox microspheres,which allowed for on-demand controlled-release of Dox.The biomimetic structure of porcine acellular dermal matrix(PADM)can significantly accelerate the wound healing process under the synergistic effect of electrical stimulation(ES).PADM-MX-Ag-Si@Dox has demonstrated remarkable antimicrobial and elec-trophysiological activities,thereby establishing a robust basis for enhancing wound healing and facilitat-ing real-time postoperative tumor surveillance.Extensive in vitro and in vivo investigations have substan-tiated that the combined utilization of PADM-MX-Ag-Si@Dox and ES results in a proactive amalgamation of melanoma postoperative relapse prevention,wound healing,and real-time postoperative surveillance,thereby establishing a potent therapeutic approach for postoperative cancer adjuvant therapy and paving the way for novel precision medical care.

Acellular dermal matrixMulti-responsive propertiesDrug-delivery systemMelanoma postoperative therapy,Wound healing

Manhui Zheng、Xuechuan Wang、Jiamin Zhang、Ouyang Yue、Jingyu Zhang、Zhongxue Bai、Huie Jiang、Jiang Wu、Ling Wen、Xinhua Liu

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College of Bioresources Chemical and Materials Engineering,Shaanxi University of Science & Technology,Xi'an 710021,China

Institute of Biomass & Functional Materials,Shaanxi University of Science & Technology,Xi'an 710021,China

Department of General Surgery,The Second Affiliated Hospital of Soochow University,Suzhou 215004,China

School of Pharmaceutical Sciences,Key Laboratory of Biotechnology and Pharmaceutical Engineering,Wenzhou Medical University,Wenzhou 325035,China

Department of Radiology,Dushu Lake Hospital Affiliated to Soochow University,Suzhou 215000,China

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National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaKey Research and the Development Program of Shaanxi ProvinceScientific Research Plan Projects of the Shaanxi Education DepartmentYoung Talent Support Program Project of Shaanxi University of Science and Technology Association

22278257218040842022GY-27222JY01320200424

2024

10.1016/j.jmst.2023.12.010

材料科学技术(英文版)
中国金属学会 中国材料研究学会 中国科学院金属研究所

材料科学技术(英文版)

CSTPCD
影响因子：0.657
ISSN：1005-0302
年,卷(期)：2024.188(21)
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