首页|A spatiotemporal"bulk erosion"mode in selective laser melted magnesium alloys and the resulting adverse cell & tissue responses

A spatiotemporal"bulk erosion"mode in selective laser melted magnesium alloys and the resulting adverse cell & tissue responses

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Selective laser melting(SLM)has attracted great attention in the fabrication of magnesium-based biodegradable implants.However,current SLMed magnesium alloys are generally suffered from rapid corrosion,which is deadly detrimental to their use.Herein,we thoroughly revealed why they are so vulnerable to corrosion through a typical SLMed AZ91D material model.An abnormally spatiotempo-ral"bulk erosion"mechanism was found,not the well-known"surface corrosion"mode of traditionally plastic-deformed alloys.The unique microstructure derived from SLM possesses high chemical reactivity,which is favorable for interactional attacks of fast fluid penetration,severe local corrosion and intensive micro-galvanic corrosion.Thus,it brings two orders of magnitude in corrosion rates compared with its plastic-deformed counterparts.In vitro,such fast-corrosion induced apparent cytotoxicity,cell damage,and further apoptosis to rat and mouse derived mesenchymal stem cells.In vivo,the material disinte-grates into small pieces in a short period,and results in unexpected bone destruction and long-lasting foreign body reactions in Sprague Dawley rats.Close attention should be paid to this issue before SLMed Mg-based implants being applied in patients.

Selective laser meltingBiodegradable magnesiumBulk erosionMicrostructural defectAdverse biological response

Dong Bian、Zhipei Tong、Gencheng Gong、He Huang、Guixing Cai、Xingchen Yan、Hui Yu、Cheng Chang、Yufeng Zheng

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Medical Research Institute,Department of Orthopedics,Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences),Southern Medical University,Guangzhou 510080,China

School of Medicine,South China University of Technology,Guangzhou 510006,China

School of Materials Science and Engineering,Zhengzhou University,Zhengzhou 450003,China

Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,China

Guangdong Provincial Key Laboratory of Modern Surface Engineering Technology,National Engineering Laboratory of Modern Materials Surface Engineering Technology,Institute of New Materials,Guangdong Academy of Sciences,Guangzhou 510651,China

Department of Orthopaedic Surgery,Guangzhou Key Laboratory of Spine Disease Prevention and Treatment,Guangdong Provincial Key Laboratory of Major Obstetric Diseases,Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou 510515,China

School of Materials Science and Engineering,Peking University,Beijing 100871,China

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2024

10.1016/j.jmst.2024.01.075

材料科学技术(英文版)
中国金属学会 中国材料研究学会 中国科学院金属研究所

材料科学技术(英文版)

CSTPCD
影响因子：0.657
ISSN：1005-0302
年,卷(期)：2024.198(31)