首页|Composite demineralized bone matrix nanofiber scaffolds with hierarchical interconnected networks via eruptive inorganic catalytic decomposition for osteoporotic bone regeneration

Composite demineralized bone matrix nanofiber scaffolds with hierarchical interconnected networks via eruptive inorganic catalytic decomposition for osteoporotic bone regeneration

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Demineralized bone matrix(DBM)is one of the standard biomaterials used to fill surgical bone defects in general orthopedic procedures.However,current DBM products come in the form of powder or viscous solutions that fail to mimic the natural hierarchical structure of bone while also using large amounts of valuable material.To overcome this,compact fibrous DBM/polymer(fDBM)composites were prepared via electrospinning.Then,by exploiting the catalytic decomposition of hydrogen peroxide,oxygen pockets are formed in the scaffold imparting it with a hierarchical porous structure similar to bone(Op-fDBM).These pockets created by bubbles of oxygen help give the scaffold a mechanically stable shape while the incorporated DBM supports cell adhesion and growth.In vivo evaluations reveal that fDBM increased bone volume by 41.7％while Op-fDBM increased bone volume by 68.6％.Significant increases in regenerated bone volume with the use of minimal amounts of DBM in fiber form go to show the great potential of this work in the field of bone regeneration.

Demineralized bone matrixHierarchical networksCatalytic decompositionBone regeneration

Sung Won Ko、Joshua Lee、Ji Yeon Lee、Jeong Hwi Cho、Sunny Lee、Hak Su Jang、Chan Hee Park、Hyun Jin Tae、Cheol Sang Kim、Young Min Oh

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Department of Bionanosystem Engineering,Jeonbuk National University,Jeonju,Republic of Korea

Department of Bionanotechnology and Bioconvergence Engineering,Graduate School,Jeonbuk National University,Jeonju,Republic of Korea

Department of Mechanical Design Engineering,Graduate School,Jeonbuk National University,Jeonju,Republic of Korea

College of Veterinary Medicine and Bio-safety Research Institute,Jeonbuk National University,Iksan,Republic of Korea

R&D Center,CGBIO Inc,Seongnam,Republic of Korea

Division of Mechanical Design Engineering,Jeonbuk National University,Jeonju,Republic of Korea

Department of Neurosurgery,Research Institute of Clinical Medicine,Jeonbuk National University Medical,School and Hospital,Jeonju,Republic of Korea

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2024

10.1016/j.jmst.2024.02.018

材料科学技术(英文版)
中国金属学会 中国材料研究学会 中国科学院金属研究所

材料科学技术(英文版)

CSTPCD
影响因子：0.657
ISSN：1005-0302
年,卷(期)：2024.199(32)