Composite demineralized bone matrix nanofiber scaffolds with hierarchical interconnected networks via eruptive inorganic catalytic decomposition for osteoporotic bone regeneration

Sung Won Ko ¹Joshua Lee ¹Ji Yeon Lee ²Jeong Hwi Cho ³Sunny Lee ⁴Hak Su Jang ⁵Chan Hee Park ⁶Hyun Jin Tae ³Cheol Sang Kim ⁶Young Min Oh⁷

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作者信息

1. Department of Bionanosystem Engineering,Jeonbuk National University,Jeonju,Republic of Korea;Department of Bionanotechnology and Bioconvergence Engineering,Graduate School,Jeonbuk National University,Jeonju,Republic of Korea
2. Department of Mechanical Design Engineering,Graduate School,Jeonbuk National University,Jeonju,Republic of Korea
3. College of Veterinary Medicine and Bio-safety Research Institute,Jeonbuk National University,Iksan,Republic of Korea
4. Department of Bionanosystem Engineering,Jeonbuk National University,Jeonju,Republic of Korea
5. R&D Center,CGBIO Inc,Seongnam,Republic of Korea
6. Department of Bionanosystem Engineering,Jeonbuk National University,Jeonju,Republic of Korea;Department of Bionanotechnology and Bioconvergence Engineering,Graduate School,Jeonbuk National University,Jeonju,Republic of Korea;Division of Mechanical Design Engineering,Jeonbuk National University,Jeonju,Republic of Korea
7. Department of Neurosurgery,Research Institute of Clinical Medicine,Jeonbuk National University Medical,School and Hospital,Jeonju,Republic of Korea
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Abstract

Demineralized bone matrix(DBM)is one of the standard biomaterials used to fill surgical bone defects in general orthopedic procedures.However,current DBM products come in the form of powder or viscous solutions that fail to mimic the natural hierarchical structure of bone while also using large amounts of valuable material.To overcome this,compact fibrous DBM/polymer(fDBM)composites were prepared via electrospinning.Then,by exploiting the catalytic decomposition of hydrogen peroxide,oxygen pockets are formed in the scaffold imparting it with a hierarchical porous structure similar to bone(Op-fDBM).These pockets created by bubbles of oxygen help give the scaffold a mechanically stable shape while the incorporated DBM supports cell adhesion and growth.In vivo evaluations reveal that fDBM increased bone volume by 41.7％while Op-fDBM increased bone volume by 68.6％.Significant increases in regenerated bone volume with the use of minimal amounts of DBM in fiber form go to show the great potential of this work in the field of bone regeneration.

Key words

Demineralized bone matrix/Hierarchical networks/Catalytic decomposition/Bone regeneration

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出版年

2024

材料科学技术(英文版)

中国金属学会中国材料研究学会中国科学院金属研究所

材料科学技术(英文版)

CSTPCDCSCD

影响因子：0.657

ISSN：1005-0302

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