首页|Dual-functional polyetheretherketone surface modification for enhanced osseointegration and antibacterial activity in pH-responsive manner
Dual-functional polyetheretherketone surface modification for enhanced osseointegration and antibacterial activity in pH-responsive manner
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Polyetheretherketone(PEEK)has been recognized for its immense potential in hard tissue repair appli-cations due to its mechanical properties resembling those of natural bones.However,the inherent bioin-ertness of pristine PEEK results in insufficient osseointegration.Moreover,implant-associated infection(IAI)has become a serious threat in orthopedic surgery.These risks usually lead to implant loosening,delayed healing,and even the failure of implantation,hampering many clinical applications of PEEK.In this study,we present a facile strategy to endow PEEK implants with enhanced osseointegration and pH-responsive antibacterial activity.Briefly,pristine PEEK was first treated with mixed acids to obtain a porous structure(referred to as SNPEEK),and then the metal-phenolic networks(MPN)coating was prepared using layer-by-layer(LbL)assembly consisting of Sr2+and tannin acid(TA)(referred to as ST coating).The results demonstrated that the dual-functional PEEK displayed enhanced antibacterial activ-ity in pH-responsive manner.At pH 7.4,the antibacterial ratios were 71.72％and 66.79％against Staphylo-coccus aureus(MSSA,ATCC 25,923)and methicillin-resistant Staphylococcus aureus(MRSA,ATCC BAA-40),respectively.Remarkably,at pH 5.5,the antibacterial activities significantly increased,resulting in killing ratios of 99.98％and 100％,respectively.Furthermore,the dual-functional PEEK promoted osteogenic dif-ferentiation of pre-osteoblasts(MC3T3-E1)and migration of human umbilical vascular endothelial cells(HUVECs).In addition,the dual-functional PEEK demonstrated effective anti-infection ability and desir-able new bone formation ability in vivo compared to both pristine PEEK and SNPEEK implants.Overall,this study provides a promising strategy to endow PEEK implants with effective osseointegration and anti-infective ability,representing a prospective solution to address current clinical challenges associated with PEEK implants.
Rui Ding、Zhang Yuan、Ke Wang、Pandi Peng、Jiaheng Liang、Kun Wang、Ke Lin、Hanxue Wu、Peng Li
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Frontiers Science Center for Flexible Electronics(FSCFE),Xi'an Institute of Flexible Electronics(IFE),Xi'an Institute of Biomedical Materials and Engineering(IBME),Northwestern Polytechnical University(NPU),Xi'an,710072,China
Xi'an Key Laboratory of Stem Cell and Regenerative Medicine Institute of Medical Research,Northwestern Polytechnical University,Xi'an,710072,China
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