Although sulfadiguanide has a broad-spectrum antibacterial effect as a drug used in clinical practice,excessive intake is fatal to the human body,so in order to determine the content of sulfadiguanide in drugs and reduce the cost of detection,a new chemiluminescence method for the determination of sulfadiguanide content by combined flow injection technology was established.Under the acid condition,the sulfadiguanide is determined by potassium permanganate-formaldehyde luminescent system combined with flow injection chemiluminescence analyzer.The result show that the linear range is 5×10-5～6×10-4 mol·L-1,the detection limit is 6 × 10-7 mol·L-1,the relative standard deviation is 1.1％(n=11,Csulfadiguanide=2 × 10-4 mol·L-1),the recovery is 97％～103％.Using this method has been successful to the detection of sulfadiguanide recognition with satisfactory result.
关键词
磺胺胍/流动注射/化学发光/高锰酸钾-甲醛体系
Key words
sulfadiguanide/flow injection/chemiluminescence/potassium permanganate-formaldehyde system
维普
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