Effects of soy oligosaccharides and peptides on vasoactive substances and apolipoprotein levels in hyperlipidemia rats
Objective To investigate effects of soy oligosaccharides(SOS) and soy peptides(SOP) on antioxidative activity and fecal bile acid excretion in hyperlipidemia rats. Methods Sixty healthy SD rats were randomly divided into five groups:They were fed with normal diet(NCG group),high-fatty diet( HCG group) ; HF diet + 2% SOS(SOS group) ; HF diet + 3% SOP(SOP group) ; HF diet + 2% SOS +3% SOP(SOSP group) for 8 weeks. SOD activity and MDA content in Serum and liver of rats were measured and the content of fecal bile acid was detected. In addition,fat accumulation in liver was observed- Results SOS and SOP,especially their complex intervention,were able to decrease MDA concentration in serum and liver remarkably,fortify fecal bile acid excretion,and inhibit fat accumulation in liver,while no obvious influence of SOS and SOP on SOD activity was observed. Conclusion SOS and SOP can decrease MDA synthesis,attenuate lipid peroxidation,and modulate cholesterol metabolism effectively by promoting fecal bile acid excretion to prevent hyperlipidemia and atherosclerosis,which is more effective when both together.
国家科技期刊平台
NSTL
万方数据
维普
