PDK1和Ki-67表达水平与卵巢浆液性癌患者生存及预后的关系
Analysis on correlation between PDK 1 and Ki-67 expression levels with survival and prognosis of patients with ovarian serous carcinoma
杨米 1王佳 1陈燕1
作者信息
- 1. 华北理工大学附属医院妇产科,河北唐山 063000
- 折叠
摘要
目的 分析丙酮酸脱氢酶激酶1(PDK1)、Ki-67表达水平与卵巢浆液性癌(OSC)患者生存及预后的关系.方法 收集2000年1月至2020年6月于该院行手术治疗的93例OSC患者的癌组织,采用免疫组织化学法检测组织中PDK1及Ki-67表达水平,采用单因素分析及二分类logistic回归模型分析PDK1、Ki-67表达水平与OSC患者临床病理特征的关系.分析PDK1、Ki-67表达水平与3年内复发及铂耐药的关系.采用Kaplan-Meier生存曲线分析PDK1、Ki-67表达水平对OSC患者生存及预后的影响.结果 PDK1及Ki-67表达水平与国际妇产科联盟(FIGO)分期、组织分化级别、淋巴转移、腹水形成、腹水阳性有关(P＜0.05);PDK1高表达是OSC患者FIGO分期晚期(Ⅲ～Ⅳ期)、淋巴转移及腹水阳性的危险因素(P＜0.05);Ki-67高表达是OSC患者FIGO分期晚期(Ⅲ～Ⅳ)及腹水形成的危险因素(P＜0.05).PDK1、Ki-67高表达者3年内复发率及铂耐药率均明显高于低表达者(P＜0.05);PDK1、Ki-67高表达者的无进展生存期(PFS)、总生存期(OS)及5年生存率均明显低于低表达者(P＜0.05).结论 PDK1、Ki-67表达水平在OSC患者的生存及预后判断中具有重要作用.
Abstract
Objective To analyze the relationship between the expression levels of pyruvate dehydro-genase kinase 1(PDK 1)and Ki-67 with the survival and prognosis of the patients with ovarian serous carci-noma(OSC).Methods The cancer tissues of 93 patients with OSC treated by surgery in this hospital from January 2000 to June 2020 were collected,and the expression levels of PDK1 and Ki-67 in the tissues were de-tected by immunohistochemistry.The relationship between the expression levels of PDK1 and Ki-67 with the clinicopathological characteristics of the patients with OSC was analyzed by the single factor and binary logis-tic regression model.The relationship between the PDK1 and Ki-67 expression levels with the recurrence and platinum resistance within 3 years was analyzed.The Kaplan-Meier survival curve was adopted to analyze the effect of PDKI and Ki-67 expression levels on the survival and prognosis in the patients with OSC.Results The expression levels of PDK1 and Ki-67 were related with the International Federation of Gynecology and Obstetrics(FIGO)stage,tissue differentiation level,lymphatic metastasis,ascites formation and positive asci-tes(P＜0.05).The high expression of PDK1 was a risk factor for the late FIGO stage(Ⅲ-Ⅳ),lymphatic metastasis and ascites positive in the patients with OSC(P＜0.05);the high expression of Ki-67 was a risk factor for the late FIGO stage(Ⅲ-Ⅳ)and ascites formationin in the patients with OSC(P＜0.05).The re-currence rate and platinum resistance rate within 3 years in the patients with PDKi and Ki-67 high expressions were significantly higher than those in the patients with low expressions(P＜0.05).The progression-free survival(PFS),overall survival(OS)and 5-year survival rate in the patients with high PDK1 and Ki-67 ex-pressions were significantly lower than those in the patients with low expressions(P＜0.05).Conclusion The expression levels of PDK 1 and Ki-67 play an important role in judging the survival and prognosis of the patients with OSC.
关键词
卵巢浆液性癌/丙酮酸脱氢酶激酶1/Ki-67/预后/复发/生存期Key words
ovarian serous carcinoma/pyruvate dehydrogenase kinase 1/Ki-67/prognosis/recurrence/survival time引用本文复制引用
基金项目
河北省医学科学研究项目(20221539)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据