前列腺癌的代谢组学研究进展
Research advances in metabolomics of prostate cancer
邹前 1郭晓 2唐晨野 2沈瑞林1
作者信息
- 1. 浙江中医药大学嘉兴学院联培基地,浙江杭州 310053
- 2. 嘉兴市第二医院泌尿外科,浙江嘉兴 314000
- 折叠
摘要
前列腺癌是目前世界上许多地区最常见的男性恶性肿瘤之一,也是全球范围内男性癌症死亡的第五大原因.目前,临床上常用的前列腺癌筛查手段是血清前列腺特异性抗原(PSA)和经直肠超声引导的穿刺活检,但上述两种诊断方式存在假阴性及假阳性导致的过度诊断等相关问题.代谢组学是系统生物学的重要组成部分,其可以在肿瘤发生、发展过程中识别某些分子代谢物的微小改变.本文就如何利用代谢组学的方法发现前列腺癌患者体内三大物质的代谢产物及相关代谢途径的改变展开综述,为临床前列腺癌诊断提供新的思路.
Abstract
Prostate cancer is one of the most common male malignancies in many parts of the world and also the fifth leading cause of cancer death among men worldwide.At present,the commonly used clinical screening methods for prostate cancer are serum prostate-specific antigen(PSA)and transrectal ultrasound guided puncture biopsy.However,the above two diagnostic methods have some related problems such as over-diagnosis caused by false negative and false positive.Metabolomics is an important component of systems biol-ogy,which recognizes minor changes in certain molecular metabolites during tumorigenesis and development.This article reviewed how to use the method of metabolomics to find the metabolites of the three major sub-stances in the patients with prostate cancer and the changes of related metabolic pathways to provide the new ideas for the clinical diagnosis of prostate cancer.
关键词
前列腺癌/代谢组学/代谢产物/综述Key words
prostate cancer/metabolomics/metabolites/review引用本文复制引用
基金项目
浙江省数字医学重点实验室开放基金(SZZD202203)
浙江省嘉兴市科技计划(2023AZ31001)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据