Effects of dexmedetomidine on activation of mast cells around hematoma and neurological impairment in mouse intracerebral hemorrhage
Objective To explore the effect of dexmedetomidine on the neurological function and mast cells activation in the mouse with intracerebral hemorrhage(ICH).Methods The mouse was intraperitoneal-ly injected with dexmedetomidine at 30 min before intracerebral hemorrhage.After the preparation of intrace-rebral hemorrhage model,the neurological function,brain water content,number of mast cells around hemato-ma and expression levels of tryptase,IL-1β,TNF-α were detected.Results Compared with the control group,the neurological function score in the intracerebral hemorrhage group was significantly elevated(P＜0.05),the brain water content was significantly increased(P＜0.05),the mast cells number was significantly in-creased(P＜0.05),and the tryptase,IL-1β and TNF-α expression levels were sinificantly increased(P＜0.05);while the neurological function score in the dexmedetomidine group was significantly decreased(P＜0.05),the brain water content was significantly decreased(P＜0.05),the number of mast cells was signifi-cantly reduced and the tryptase,IL-1β and TNF-α expression levels were significantly decreased(P＜0.05).Conclusion Dexmedetomidine could inhibit the activation of mast cells around hematoma and reduce the dam-age of neurological function after mouse intracerebral hemorrhage.
dexmedetomidineintracerebral hemorrhagemast cellneurological function
万方数据
维普
