重庆医学2024,Vol.53Issue(4) :498-501,507.DOI:10.3969/j.issn.1671-8348.2024.04.004

川崎病患者冠状动脉病变的影响因素研究

Study on the influencing factors of coronary artery lesions in patients with Kawasaki disease

哈斯达尔·米地里别克 刘志强 杨玉春 张雷 木胡牙提
重庆医学2024,Vol.53Issue(4) :498-501,507.DOI:10.3969/j.issn.1671-8348.2024.04.004

川崎病患者冠状动脉病变的影响因素研究

Study on the influencing factors of coronary artery lesions in patients with Kawasaki disease

哈斯达尔·米地里别克 1刘志强 1杨玉春 1张雷 1木胡牙提2
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作者信息

  • 1. 新疆医科大学第一附属医院心脏中心,乌鲁木齐 830054
  • 2. 新疆医科大学第一附属医院心脏中心,乌鲁木齐 830054;新疆医科大学,乌鲁木齐 830017
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摘要

目的 分析川崎病(KD)患者冠状动脉病变的影响因素.方法 采用回顾性分析,选取新疆医科大学第一附属医院2020年12月至2022年12月就诊的1 500例KD患者作为研究对象,根据是否发生冠状动脉病变分为两组,冠状动脉病变者886例纳入试验组,非冠状动脉病变者614例纳入对照组,采用单因素、多因素logistic回归分析冠状动脉病变的危险因素.结果 logistic回归分析结果表明,患者发热持续时间>10d、Gensini积分高,N-端脑利钠肽前体(NT-proBNP)、C反应蛋白(CRP)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)高表达可能是KD患者冠状动脉病变的危险因素(P<0.05).结论 临床诊疗中应针对危险因素,应及早给予针对性干预处理,最大限度预防KD患者冠状动脉病变发生.

Abstract

Objective To analyze the influencing factors of coronary artery lesions in patients with Ka-wasaki disease(KD)in Xinjiang.Methods A total of 1 500 KD patients who were treated in the First Affilia-ted Hospital of Xinjiang Medical University from December 2020 to December 2022 were selected as the re-search objects.According to whether coronary artery disease occurred,they were divided into two groups.886 patients with coronary artery lesions were included in the experimental group,and 614 patients without coro-nary artery lesions were included in the control group.Univariate and multivariate logistic regression analysis was used to analyze the risk factors of coronary artery lesions.Results The results of logistic regression anal-ysis showed that the duration of fever(>10 d),high Gensini score,high level of N-terminal pro-brain natri-uretic peptide(NT-proBNP),C-reactive protein(CRP),total cholesterol(TC),low-density lipoprotein cho-lesterol(LDL-C)and triglycerides(TG)may be risk factors for coronary artery lesions(P<0.05).Conclusion In clinical diagnosis and treatment,targeted intervention should be given as early as possible to prevent the occurrence of coronary artery lesions.

关键词

川崎病/冠状动脉病变/危险因素/回归分析

Key words

kawasaki disease/coronary artery lesions/risk factors/regression analysis

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基金项目

国家自然科学基金项目(82160067)

天山英才-科技创新领军人才项目(2022TSYCLJ0065)

新疆维吾尔自治区科学技术厅杰出青年科技人才项目(2022D01E23)

出版年

2024
重庆医学
重庆市卫生信息中心,重庆市医学会

重庆医学

CSTPCD
影响因子:1.797
ISSN:1671-8348
参考文献量25
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