Effects of blood irradiation on the release of red blood cell microparticles from suspended red blood cells and deep vein thrombosis in trauma patients
Objective To explore the effect of blood irradiation on the release of red blood cell microp-articles (RMP) in suspended red blood cells (SRBC) and the formation of deep vein thrombosis (DVT) in trauma patients.Methods In 2022,105 cases of unirradiated SRBC and 105 cases of irradiated SRBC blood braid were collected to detect the changes of RMP and electrolyte with storage time.A total of 297 trauma pa-tients from January 2018 to April 2023 were collected,including 148 patients without blood transfusion (the non-transfusion group) and 149 patients with red blood cell (RBC) transfusion (the RBC transfusion group), including 76 patients without SRBC transfusion (the non-irradiation group) and 73 patients with SRBC trans-fusion (the irradiation group).The differences in the incidence of DVT among the groups were analyzed.Re-sults Compared with the non-irradiation SRBC,RMP and K+ in the irradiation SRBC increased from [(5280±402) particles/μL vs. (1839±384) particles/μL and (14.1±1.4) mmol/L vs. (5.8±0.3)mmol/L] on day 3 to [(57393±3966) particles/μL vs. (32310±2077) particles/μL and (31.3±1.1) mmol/L vs. (19.8±1.9) mmol/L] on day 42.The RBC transfusion group had a higher incidence of DVT than the non-transfusion group (30.2％ vs. 11.5％,P<0.001).The incidence of DVT in the irradiation group was higher than that in the non-irradiation group (38.4％ vs. 22.4％,P<0.05).Transfusion of irradiated SRBC was as-sociated with an increased incidence of DVT (OR=2.16,95％CI:1.06-4.42,P=0.03),and the incidence of DVT increased with the increase of the percentage of input irradiated SRBC.Conclusion After SRBC irradia-tion,RMP increases faster,and SRBC transfusion increases the risk of DVT in trauma patients,and the inci-dence is positively correlated with the percentage of irradiated SRBC.
万方数据
维普
