Correlation between serum irisin,Metrnl levels and in-stent restenosis after PCI
Objective To study the correlation between serum irisin,nickel striated protein-like protein (Metrnl) levels and in-stent restenosis (ISR) after percutaneous coronary intervention (PCI).Methods From October 2021 to March 2023,a total of 257 patients with coronary artery disease who were hospitalized in Wei-fang People's Hospital,underwent PCI and used the second-generation drug-eluting stent were selected as subjects.Among them,47 patients with ISR were included in the ISR group,and 210 patients without ISR were included in the non-ISR group.A total of 50 healthy people who underwent physical examination in the hospital during the same period were selected as the healthy control group.The clinical data of patients were collected and analyzed.The levels of serum irisin and Metrnl were detected by ELISA.The influencing factors of ISR after PCI were analyzed by logistic regression.The predictive value of irisin and Metrnl levels on ISR after PCI was analyzed by receiver operating characteristic (ROC) curve.Results The levels of irisin and Metrnl in the ISR group were lower than those in the non-ISR group and healthy control group,the levels of irisin and Metrnl in the non-ISR group were lower than those in the healthy control group,and the differences were statistically significant (P<0.05).The Metrnl level was positively correlated with irisin level (r=0.768,P<0.001).There were significant differences in diabetes history,smoking history,adenosine diphos-phate (ADP) inhibition rate,total stent length between the ISR group and non-ISR group (P<0.05).Elevat-ed D-dimer level was a risk factor for ISR,while irisin,Metrnl levels,ADP inhibition rate and direct bilirubin were protective factors for ISR (P<0.05).Conclusion Coronary heart disease patients with decreased levels of irisin and Metrnl are prone to ISR after PCI.The combined detection of irisin and Metrnl has a certain pre-dictive value for ISR after PCI.
coronary artery diseasepercutaneous coronary interventionin-stent restenosisirisinnickel striated protein-like protein
万方数据
维普
