Research progress of Helicobacter pylori infection related immune thrombocytopenia
Immune thrombocytopenia (ITP) is an acquired autoimmune disease characterized by de-creased platelet production and increased destruction.It is widely believed that its onset is related to various factors such as humoral immunity,cellular immunity,genetic susceptibility,abnormal gene expression,and in-fection.Helicobacter pylori (Hp) is susceptible in the population,and is closely related to gastrointestinal dis-eases such as gastritis and peptic ulcers.Recent studies have found that Hp may also be associated with the oc-currence of hematological disease,such as ITP.The mechanism of Hp induced ITP involves multiple aspects, including Hp virulence factors,increased monocyte phagocytic function,induction of platelet aggregation and activation,imbalance of dendritic cells and T helper lymphocytes,and regional and genetic factors.This article mainly reviewed the research progress on the pathogenesis of ITP induced by Hp infection,providing new re-search ideas for the treatment of ITP.
万方数据
维普
