Role of serum D-dimer and PAF-AH in auxiliary diagnosis and curative effect evaluation of cutaneous vasculitis
Objective To investigate the changes of serum D-dimer and platelet activating factor acetyl-hydrolase(PAF-AH)levels during the treament process in the patients with cutaneous vasculitis(CV),and to judging the evaluation value of auxiliary diagnosis and therapeutic effect.Methods A total of 84 patients with CV admitted and treated in this hospital from February 2020 to February 2023 were selected as the ob-servation group,including 31 cases of allergic CV,32 cases of allergic purpura and 21 cases of nodular CV,and 50 healthy people undergoing physical examination during the same period were selected as the control group.Serum D-dimer and PAF-AH levels were compared between the two groups.The curative effect of the obser-vation group was evaluated after two weeks of treatment.The D-dimer and PAF-AH levels were compared a-mong the patients with different curative effects.The receiver operating characteristic(ROC)curve was a-dopted to analyze the efficeincy of D-dimer and PAF-AH for diagnosing CV and evaluating the treatment effect.Results The serum D-dimer of the observation group was higher than that of the control group,and the PAF-AH level was lower than that of the control group(P＜0.05).The level of D-dimer in the patients with allergic VC,anaphylactoid purpura and nodular VC was higher than that in the control group,while the level of PAF-AH was lower than that in the control group(P＜0.05).The area under the curve(AUC)val-ues of D-dimer and PF-AH for diagnosing CV were 0.754 and 0.712(P＜0.05),and there was no statistical difference between them(P＞0.05).After two weeks of treatment,11 cases(13.10％)were cured,23 cases(27.38％)had obvious effect,27 cases(29.76％)were effective,and 23 cases(27.38％)were ineffective.The clinical effective rate was 72.62％.Compared with before treatment,the level of D-dimer after treatment in the observation group was decreased and the level of PAF-AH was increased(P＜0.05).Compared with the inef-fective patients,the level of D-dimer in the patients with cure,significant effect and effect was lower,and the level of PAF-AH was higher(P＜0.05).The area under the curve(AUC)values of D-dimer and PAF-AH for evaluating the treatment effect were 0.785 and 0.718 respectively(P＜0.05).Conclusion Serum D-di-mer increased and PAF-AH decreased in CV patients.These two indexes could serve as the reference for the auxiliary diagnosis and curative effect judgment of CV.
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