高压氧同步脑电仿生电刺激治疗一氧化碳中毒迟发性脑病疗效分析
Effect analysis of hyperbaric oxygen synchronous electroencephalograph bionic electrical stimulation in treatment of delayed encephalopathy after carbon monoxide poisoning
张玉 1武艳芳 2傅永旺2
作者信息
- 1. 内蒙古自治区人民医院医学高压氧治疗科,呼和浩特 010017;康复医学四川省重点实验室,成都 610041
- 2. 内蒙古自治区人民医院医学高压氧治疗科,呼和浩特 010017
- 折叠
摘要
目的 探讨高压氧同步脑电仿生电刺激治疗一氧化碳中毒迟发性脑病(DEACMP)患者的疗效.方法 选取2021年1月至2022年12月于内蒙古自治区人民医院就诊的117例DEACMP患者为研究对象,按随机数字法分为对照组(n=59)和研究组(n=58).对照组给予高压氧治疗,研究组给予高压氧同步脑电仿生电刺激仪治疗.分别于治疗前和治疗后30、90 d应用简易智力状态检查量表(MMSE)、日常生活活动能力量表(BI)及事件相关电位-P300(ERP-P300)对患者进行认知功能和日常生活活动能力评估.结果 治疗前两组MMSE评分、BI及ERP-P300波形比较,差异无统计学意义(P＞0.05).与治疗前比较,治疗后30、90 d两组MMSE评分、BI增加,ERP-P300潜伏期缩短、波幅增高,差异有统计学意义(P＜0.05).与治疗后30 d比较,治疗后90 d MMSE评分、BI更高,ERP-P300潜伏期更短、波幅更高,差异有统计学意义(P＜0.05).与对照组比较,治疗90 d研究组MMSE评分、BI更高,ERP-P300潜伏期更短、波幅更高,差异有统计学意义(P＜0.05).结论 高压氧同步脑电仿生电刺激治疗DEACMP较高压氧单独治疗效果更佳.
Abstract
Objective To explore the effect of hyperbaric oxygen synchronous electroencephalograph bionic electrical stimulation in the treatment of patients with delayed encephalopathy after acute carbon mon-oxide poisoning(DEACMP).Methods A total of 117 patients with DEACMP in the Inner Mongolia Autono-mous Region People's Hospital from January 2021 to December 2022 were selected as the research subjects and divided into the control group(n=59)and research group(n=58)according to the random number method.The control group was treated with hyperbaric oxygen,while the research group was treated with hy-perbaric oxygen synchronous electroencephalograph bionic electrical stimulation.The Mini-Mental State Ex-amination Scale(MMSE),Activity of Daily Living Scale(BI)and Event-related Potential-P300(ERP-P300)were used to evaluate the abilities of cognotive function and activities of daily living in the patients before treatment and on 30,90 d after treatment.Results There were no statistically significant differences in the MMSE score,BI and ERP-P300 waveform before treatment between the two groups(P＞0.05).Compared with before treatment,the MMSE score and BI on 30,90 d after treatment in the two groups were increased,ERP-P300 latent period was decreased and amplitude was increased,and the differences were statistically sig-nificant(P＜0.05).Compared with those on 30 d after treatment,MMSE score and BI on 90 d after treatment were higher,ERP-P300 latent period was shorter and amplitude was higher,and the difference was statistically significant(P＜0.05).Compared with the control group,the MMSE score and BI on 90 d of treatment in the research group were higher,the latent period of ERP-P300 was shorter and the amplitude was higher,and the differences were statistically significant(P＜0.05).Conclusion The effect of hyperbaric oxygen synchronous electroencephalograph bionic electrical stimulation in treating DEACMP is better than hyperbaric oxygen ther-apy alone.
关键词
一氧化碳中毒迟发性脑病/高压氧/脑电仿生电刺激/认知功能/生活自理能力Key words
delayed encephalopathy after acute carbon monoxide poisoning/hyperbaric oxygen/electro-encephalographic bionic electrical stimulation/cognitive function/self-care ability of daily living引用本文复制引用
基金项目
内蒙古自治区卫生健康科技计划项目(202201051)
康复医学四川省重点实验室开放课题项目(KFYXSZDSYS-03)
出版年
2024
国家科技期刊平台
NSTL
万方数据