首页|高压氧同步脑电仿生电刺激治疗一氧化碳中毒迟发性脑病疗效分析

高压氧同步脑电仿生电刺激治疗一氧化碳中毒迟发性脑病疗效分析

Effect analysis of hyperbaric oxygen synchronous electroencephalograph bionic electrical stimulation in treatment of delayed encephalopathy after carbon monoxide poisoning

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目的 探讨高压氧同步脑电仿生电刺激治疗一氧化碳中毒迟发性脑病(DEACMP)患者的疗效.方法 选取2021年1月至2022年12月于内蒙古自治区人民医院就诊的117例DEACMP患者为研究对象,按随机数字法分为对照组(n=59)和研究组(n=58).对照组给予高压氧治疗,研究组给予高压氧同步脑电仿生电刺激仪治疗.分别于治疗前和治疗后30、90 d应用简易智力状态检查量表(MMSE)、日常生活活动能力量表(BI)及事件相关电位-P300(ERP-P300)对患者进行认知功能和日常生活活动能力评估.结果 治疗前两组MMSE评分、BI及ERP-P300波形比较,差异无统计学意义(P＞0.05).与治疗前比较,治疗后30、90 d两组MMSE评分、BI增加,ERP-P300潜伏期缩短、波幅增高,差异有统计学意义(P＜0.05).与治疗后30 d比较,治疗后90 d MMSE评分、BI更高,ERP-P300潜伏期更短、波幅更高,差异有统计学意义(P＜0.05).与对照组比较,治疗90 d研究组MMSE评分、BI更高,ERP-P300潜伏期更短、波幅更高,差异有统计学意义(P＜0.05).结论 高压氧同步脑电仿生电刺激治疗DEACMP较高压氧单独治疗效果更佳.
Objective To explore the effect of hyperbaric oxygen synchronous electroencephalograph bionic electrical stimulation in the treatment of patients with delayed encephalopathy after acute carbon mon-oxide poisoning(DEACMP).Methods A total of 117 patients with DEACMP in the Inner Mongolia Autono-mous Region People's Hospital from January 2021 to December 2022 were selected as the research subjects and divided into the control group(n=59)and research group(n=58)according to the random number method.The control group was treated with hyperbaric oxygen,while the research group was treated with hy-perbaric oxygen synchronous electroencephalograph bionic electrical stimulation.The Mini-Mental State Ex-amination Scale(MMSE),Activity of Daily Living Scale(BI)and Event-related Potential-P300(ERP-P300)were used to evaluate the abilities of cognotive function and activities of daily living in the patients before treatment and on 30,90 d after treatment.Results There were no statistically significant differences in the MMSE score,BI and ERP-P300 waveform before treatment between the two groups(P＞0.05).Compared with before treatment,the MMSE score and BI on 30,90 d after treatment in the two groups were increased,ERP-P300 latent period was decreased and amplitude was increased,and the differences were statistically sig-nificant(P＜0.05).Compared with those on 30 d after treatment,MMSE score and BI on 90 d after treatment were higher,ERP-P300 latent period was shorter and amplitude was higher,and the difference was statistically significant(P＜0.05).Compared with the control group,the MMSE score and BI on 90 d of treatment in the research group were higher,the latent period of ERP-P300 was shorter and the amplitude was higher,and the differences were statistically significant(P＜0.05).Conclusion The effect of hyperbaric oxygen synchronous electroencephalograph bionic electrical stimulation in treating DEACMP is better than hyperbaric oxygen ther-apy alone.

delayed encephalopathy after acute carbon monoxide poisoninghyperbaric oxygenelectro-encephalographic bionic electrical stimulationcognitive functionself-care ability of daily living

张玉、武艳芳、傅永旺

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内蒙古自治区人民医院医学高压氧治疗科,呼和浩特 010017

康复医学四川省重点实验室,成都 610041

一氧化碳中毒迟发性脑病 高压氧 脑电仿生电刺激 认知功能 生活自理能力

内蒙古自治区卫生健康科技计划项目康复医学四川省重点实验室开放课题项目

202201051KFYXSZDSYS-03

2024

10.3969/j.issn.1671-8348.2024.07.014

重庆医学
重庆市卫生信息中心,重庆市医学会

重庆医学

CSTPCD
影响因子：1.797
ISSN：1671-8348
年,卷(期)：2024.53(7)
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