Analysis on clinical features and risk factors of liver cirrhosis portal vein thrombosis associated with metabolism-associated fatty liver disease
Objective To analyze the clinical features and related risk factors of liver cirrhosis portal vein thrombosis(PVT)related with metabolic associated fatty liver disease(MAFLD).Methods The clinical data of 120 patients with MAFLD related cirrhosis admitted and treated in this hospital were analyzed retro-spectively.Among them,33 patients developing PVT served as the PVT group and 87 patients without PVT occurrence as the control group.The demographic data,past history,complications,laboratory indexes and imageological indexes of the patients were collected.The Child-Pugh scores were calculated and the multivari-ate logistic regression was adopted to analyze the independent risk factors for MAFLD related liver cirrhosis PVT formation.Results There were no statistically significant differences in the age,sex,smoking history,complicating hypertension,complicating diabetes,complicating ascites,hepatic encephalopathy,spontaneous peritonitis and Child-Pugh grade had no statistical differences between the two groups(P＞0.05),while com-plicating coronary heart disease,splenectomy history,complicating esophageal and gastric varices,digestive tract hemorrhage and the proportion of hypersplenism had statistical difference(P＜0.05).ALT,AST,alka-line phosphatase(ALP),γ-glutamyl transpeptidase(GGT),total bilirubin(TBil),total bile acids(TBA),al-bumin(ALB),uric acid(UA),triglyceride(TG),WBC,PLT,prothrombin time(PT),activated partial thromboplastin time(APTT)and portal vein width distribution had statistical differences between the two groups(P＜0.0 1),but serum total cholesterol(TC),hemoglobin(Hb),thrombin time(TT)and fibrinogen(Fib)had no statistical differences(P＞0.05).The high TG level,complicating hypersplenism,complicating esophageal and gastric varices and splenectomy history were the independent risk factors for PVT formation in the patients with MAFLD-related liver cirrhosis(OR=1.547,1.717,2.704,5.257;P=0.037,0.010,0.016,0.001).Conclusion The patients with MAFLD-related cirrhosis should control the TG level to minimize the PVT formation,and for the patients with MAFLD-related liver cirrhosis complicating esophageal and gastric varices and hypersplenism,attention should be paid to PVT to facilitate early detection and intervention.The risk of subsequent PVT formation should also be considered in the preoperative evaluation of splenectomy.
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