Research progress on occurrence mechanism of cholestasis
Cholestasis is a common clinical syndrome and can be divided into extrahepatic cholestasis(EHC)and intrahepatic cholestasis(IHC)depending on the site of disease.EHC is mainly caused by biliary obstruction due to inflammatory edema,stones,tumors and roundworms,while the IHC occurrence is more complex and the specific pathogenesis is unclear,including primary cholestatic cholangitis,primary sclerosing cholangitis,intrahepatic cholestasis of pregnancy(ICP),IgG4-related sclerosing cholangitis,progressive familial intra-hepatic cholestasis and secondary intrahepatic cholestasis caused by alcoholic liver disease,chronic viral hepatitis,drug-related liver injury,etc.This article mainly summarizes the new developments in the pathogenesis studies of cholestasis and aims to provide a reference for scientific research and clinical workers in this disease.
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