摘要
目的 探讨限制能量平衡膳食模式(CRD)联合肠道微生态制剂对超重/肥胖不孕患者行新鲜周期胚胎移植妊娠结局的影响.方法 选取2019年1月至2021年12月于该院行体外受精/卵细胞质内单精子显微注射-胚胎移植助孕新鲜胚胎移植的197例患者为研究对象,根据BMI大小和是否接受CRD干预分为超重干预组(n=46)、超重对照组(n=85)、肥胖干预组(n=29)、肥胖对照组(n=37),比较各组妊娠结局相关指标及干预前后体重和体成分变化.结果 与干预前相比,超重干预组体重[(63.59±4.90)kg vs.(67.47±5.10)kg]、BMI[(25.74±1.26)kg/m2 vs.(26.58±0.75)kg/m2]、体脂百分比[(36.51±3.76)％vs.(39.21±4.26)％]、腰臀比(0.88±0.04 vs.0.91±0.04)、内脏脂肪等级(10.80±2.45 vs.12.63±2.60)、基础代谢率[(1 235.98±74.32)kcal vs.(1 254.63±77.23)kcal]明显降低(P＜0.05);肥胖干预组体重[(71.79±9.78)kg vs.(77.18±9.62)kg]、BMI[(29.04±2.96)kg/m2 vs.(31.21±2.64)kg/m2]、体脂百分比[(40.47±4.77)％vs.(43.97±3.81)％]、腰臀比(0.92±0.05 vs.0.96±0.06)、内脏脂肪等级(14.00±3.74 vs.16.59±3.15)明显降低(P＜0.05).与超重对照组比较,超重干预组移植胚胎数[(1.85±0.36)个vs.(1.96±0.19)个]更少(P＜0.05),且活胎数[(0.61±0.37)个 vs.(0.56±0.36)个]更多,活产率(43.48％vs.40.00％)更高,但差异无统计学意义(P＞0.05).与肥胖对照组比较,肥胖干预组临床妊娠率(72.41％vs.51.35％)、活产率(58.62％vs.35.14％)更高,但差异无统计学意义(P＞0.05).结论 CRD联合肠道微生态制剂可降低超重/肥胖不孕患者的体重和体脂,可能有助于提高肥胖不孕患者辅助生殖成功率.
Abstract
Objective To investigate the effects of calorie-restricted diet(CRD)combined with intesti-nal micro-ecological preparation on the clinical outcomes of overweight/obese infertile patients undergoing fresh embryo transfer cycle.Methods A total of 197 cases of fresh embryo transfer assisted by in vitro fertili-zation(IVF)/intracytoplasmic sperm injection(ICSI)-embryo transfer(ET)in the hospital from January,2019 to December,2021 were selected as the research objects,and were divided into the overweight interven-tion group(n=46),the overweight control group(n=85)and the obesity intervention group(n=85)accord-ing to the body mass index(BMI)and whether they accepted CRD intervention or not.Results Compared to before the intervention,the overweight intervention group had significantly lower body mass[(63.59±4.90)kg vs.(67.47±5.10)kg],BMI[(25.74±1.26)kg/m2 vs.(26.58±0.75)kg/m2],body fat percentage[(36.51±3.76)％vs.(39.21±4.26)％],waist to hip ratio(0.88±0.04 vs.0.91±0.04),visceral fat grade(10.80±2.45 vs.12.63±2.60),and basal metabolic rate[(1 235.98±74.32)kcal vs.(1 254.63±77.23)kcal],P＜0.05;The body mass[(71.79±9.78)kg vs.(77.18±9.62)kg],BMI[(29.04±2.96)kg/m2 vs.(31.21±2.64)kg/m2],body fat percentage[(40.47±4.77)％vs.(43.97±3.81)％],waist to hip ratio(0.92±0.05 vs.0.96±0.06),and visceral fat grade(14.00±3.74 vs.16.59±3.15)of the obesity interven-tion group were significantly reduced(P＜0.05).Compared with the overweight control group,the number of transplanted embryos(1.85±0.36 vs.1.96±0.19)in the overweight intervention group was less(P＜0.05),while the number of live births(0.61±0.37 vs.0.56±0.36)was more,the live birth rate(43.48％vs.40.00％)was higher,but there was no statistically significant difference(P＞0.05).The clinical preg-nancy rate and live birth rate in the obesity intervention group were higher than those in the control group(72.41％vs.51.35％and 58.62％vs.35.14％),with no statistical significance,but with a strong statistical significance(P＞0.05).Conclusion CRD combined with intestinal micro-ecological preparation can signifi-cantly reduce the body mass and body fat of overweight/obese infertile patients,may help improve the success rate of assisted reproduction in obese infertile patients.
基金项目
重庆市科卫联合医学科研项目(2021MSXM192)
维普
万方数据