目的 探讨肛周脓肿术后应用抗生素对肛瘘形成的影响。方法 制订检索式检索Web of Sci-ence、PubMed、Embase、Cochrane Library、万方数据库、中国知网、维普数据库及中国临床试验注册中心数据，收集肛周脓肿切开引流术后应用抗生素治疗的临床研究，筛选及评价后进行meta分析。结果 共计纳入8项研究，其中3项研究为随机对照试验，4项研究为队列研究，1项为病例对照研究;按照研究类型不同分成随机对照试验亚组和观察性研究亚组，采用随机效应模型合并分析。随机对照试验亚组meta分析结果RR=0。71，95％CI:0。30～1。69;观察性研究亚组 meta 分析结果 RR=0。61，95％CI:0。48～0。78。总 RR=0。64，95％CI:0。47～0。88。结论 肛周脓肿切开引流术后抗生素的应用对肛瘘形成有一定的预防作用。
Effect of antibiotics on anal fistula formation after perianal abscess incision and drainage:a meta-analysis
Objective To investigate the effect of antibiotics on the formation of anal fistula after peri-anal abscess surgery.Methods Database of Web of Science,PubMed,Embase,Cochrane Library,Wanfang,CNKI,VIP and China Clinical Trial Registry were searched to collect clinical studies on antibiotic therapy af-ter perianal abscess incision and drainage,and meta-analysis was performed after screening and evaluation.Results A total of eight studies were included for systematic review,including three studies were randomized controlled trials,four studies were cohort studies,and one study was case-control study.They were divided in-to randomized the controlled trial(RCT)subgroup and the observational study subgroup according to differ-ent research types,and combined analysis was conducted by using random effects model.The risk ratio(RR)of RCT subgroup was 0.71,95％CI was 0.30-1.69;The RR of observational research subgroup was 0.61,95％CI was 0.48-0.78.The total RR was 0.64,95％CI was 0.47-0.88.Conclusion The application of an-tibiotics after perianal abscess incision and drainage has a certain preventive effect on the formation of anal fis-tula.
perianal abscessincision and drainageantibioticsanal fistulameta-analysis
万方数据
维普
