Fracture is a pathological change caused by direct violent injury,indirect violent injury or cu-mulative strain,which results in the destruction of bone continuity and loss of integrity.Fracture healing is a complex biological process of bone regeneration,which can be divided into the hematoma inflammatory organi-zation stage,primitive callus formation stage and callus reconstruction and shaping stage.In the process of fracture healing,the granulation tissue grows into the hematoma site to absorb blood clots,nerves and new capillaries grow into the fracture site,large callus is formed,callus is remodeled and normal bone structure is eventually restored.In this process,there are many substances involving in the regulation of fracture healing,in which nerve growth factor (NGF) plays a certain role,NGF can promote the fracture healing through mul-tiple pathways.This article reviews the effects of nerve growth factors on fracture healing.
维普
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