首页|蛛网膜下腔出血后神经炎症与白质损伤在认知功能障碍中的作用

蛛网膜下腔出血后神经炎症与白质损伤在认知功能障碍中的作用

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蛛网膜下腔出血(SAH)是世界上第三常见的卒中类型。由于神经影像技术和血管内介入治疗的发展及健康体检的推广,其死亡率和致残率已有所下降,但患者长期的神经功能缺损和认知功能障碍并未得到明显改善,这可能与SA H后的神经炎症和白质损伤相关。既往对SAH后白质损伤缺少关注,可能是目前SAH患者预后不良的重要原因。神经炎性反应是SAH后重要的病理生理过程,SAH后的神经炎症可能加重白质损伤。该文对SAH后神经炎症和白质损伤之间的关系进行综述,以期加深关于其对SAH后认知功能影响的认识。
Role of neuroinflammation and white matter injury in cognitive dysfunction after subarachnoid hemorrhage
Subarachnoid hemorrhage (SAH) is the third common type of stroke in the world,and its mortality and disability rates have declined over the past few decades due to the advances in neuroimaging technology and endovascular interventional therapy and promotion of healthy physical examination,but long-term neurological deficits and cognitive impairment of the patients have not significantly improved,which may be related to the white matter injury (WMI) after SAH.Little attention has been paid to WMI after SAH in the past,which may be an important reason for the poor prognosis of the patients with SAH.The neuroin-flammation response is an important pathophysiological process after SAH,and the neuroinflammation after SAH can aggravate WMI.This article reviews the relationship between neuroinflammation and WMI after SAH in order to deepen the understanding of its effects on cognitive function after SAH.

subarachnoid hemorrhageneuroinflammationwhite matter injurycognitive functionreview

曹云川、曾博、李晓果、朱亚军、张晓枫、汪应文、孙晓川、郭宗铎

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重庆医科大学附属第一医院神经外科,重庆 400016

重庆医科大学附属大学城医院神经外科,重庆 401331

蛛网膜下腔出血 神经炎症 白质损伤 认知功能 综述

国家自然科学基金面上项目重庆市科卫联合医学科研重点项目

820713322020GDRC024

2024

重庆医学
重庆市卫生信息中心,重庆市医学会

重庆医学

CSTPCD
影响因子:1.797
ISSN:1671-8348
年,卷(期):2024.53(11)