Siglec在肝移植免疫调控机制中的研究进展
Research progress of Siglec in immune regulatory mechanisms of liver transplantation
罗杰夫 1龚建平 1成名翔1
作者信息
- 1. 重庆医科大学附属第二医院肝胆外科,重庆 400010
- 折叠
摘要
在各种免疫调节系统中,存在着一种表达于免疫细胞表面的跨膜受体,可选择性地发挥作用,即唾液酸结合免疫球蛋白样凝集素(Siglec)家族.抑制宿主T细胞抗原应答是诱导肝移植免疫耐受的关键因素,新近发现Siglec-15是重要的T细胞抑制分子,部分家族成员与其具有相似的结构及生物学特性,由此,推测Siglec家族的成员可能成为诱导肝脏免疫耐受的新靶点.该文对这一领域的相关文献进行综述,以Siglec-15为切入点,探讨Siglec家族在抑制宿主T细胞抗原应答及调控免疫反应中可能的作用和分子机制,为移植术后免疫调控和免疫耐受的建立提供新的思路.
Abstract
In various immunomodulatory systems,there exists a transmembrane receptor expressed on the surface of immune cells,which can play a role selectively,namely the sialic-binding immunoglobulin-like lectin(Siglec)family.Inhibition of host T cell antigen response is a key factor in inducing immune tolerance of liver transplantation.Recently,Siglec-15 has been found to be an important T cell suppressor molecule,and some of its family members have similar structure and biological characteristics.It is speculated that the mem-bers of Siglec family may be a new target for inducing liver immune tolerance.Therefore,this paper reviews the relevant literatures in this field,and takes Siglec-15 as the entry point to explore the possible role and mo-lecular mechanism of Siglec family in inhibiting host T cell antigen response and regulating immune response in order to provide the new ideas for the establishment of immune regulation and tolerance after transplanta-tion.
关键词
唾液酸结合免疫球蛋白样凝集素/肝脏移植/免疫耐受/免疫排斥/缺血再灌注/综述Key words
sialic-binding immunoglobulin-like lectin/liver transplantation/immune tolerance/immune rejection/ischemia reperfusion/review引用本文复制引用
基金项目
重庆市自然科学基金面上项目(cstc2020jcyjmsxmX0791)
重庆市科卫联合医学科研项目(2023MSXM020)
重庆市教育委员会科学技术研究项目(KJQN202000405)
出版年
2024
国家科技期刊平台
NSTL
万方数据