Effects of dexmedetomidine on oxidative stress brain injury and NOX4 expression after mouse intracerebral hemorrhage
Objective To explore the effects of dexmedetomidine on oxidative stress brain injury and nicotinamide adenine dinucleotide phosphate oxidase (NOX)4 expression after intracerebral hemorrhage in mouse.Methods The mouse intracerebral hemorrhage model was prepared after 30 min intraperitoneal injec-tion of dexmedetomidine. The neurological motor function,brain water content,NOX4 mRNA content,NOX4 protein expression level and oxidative stress levels were detected.Results Compared with the control group,the neurological motor function score in the intracerebral hemorrhage group was significantly increased (P<0.05),the brain water content was increased (P<0.05),the NOX4 mRNA and NOX4 protein expression levels were significantly increased (P<0.05),the oxidative stress level was increased;but the neurological motor function score in the dexmedetomidine group was significantly decreased (P<0.05),the brain water content was significantly decreased,the NOX4 mRNA and NOX4 protein expression levels were significantly decreased (P<0.05) and the oxidative stress level was decreased.Conclusion Dexmedetomidine could inhibit the NOX4 expression after intracerebral hemorrhage and alleviate the oxidative stress brain injury in mice.
万方数据
维普
