首页|miR-155-5p对带状疱疹性神经痛慢性化的预测作用

miR-155-5p对带状疱疹性神经痛慢性化的预测作用

扫码查看
目的 观察miR-155-5p在带状疱疹性神经痛慢性化过程中的表达及其预警作用.方法 选择带状疱疹性神经痛患者88例(HZN组)和20例健康体检者(HA组),采用逆转录-实时荧光定量PCR(RT-qPCR)方法测量血清中miR-155-5p表达,患者随访3个月后仍有疼痛的为带状疱疹后神经痛(PHN组),疼痛消失为痊愈(RC组).比较HZN组和HA组、PHN组和RC组miR-155-5p表达水平差异,计算受试者工作特征(ROC)曲线下面积(AUC)及95%CI评价miR-155-5p预测带状疱疹性神经痛慢性化的效能.结果 与HA组比较,HZN组miR-155-5p表达水平明显上调,差异有统计学意义(P<0.05);与RC组比较,PHN组带状疱疹期miR-155-5p表达水平明显上调,差异有统计学意义(P<0.05);miR-155-5p预测带状疱疹性神经痛慢性化的AUC(95%CI)为0.878(0.808~0.948).结论 带状疱疹后神经痛患者带状疱疹期血清中miR-155-5p较痊愈患者表达水平明显上调,miR-155-5p可作为带状疱疹性神经痛慢性化的重要预测指标.
Predictive effect of miR-155-5p on chronicity in herpes zoster neuralgia
Objective To observe the expression and forewarning effect of MiR-155-5p in the chronicity process of herpes zoster neuralgia (HZN).Methods A total of 88 patients with herpes zoster neuralgia (HZN group) and 20 healthy subjects undergoing physical examination (HA group) were selected.The expression level of serum miR-155-5p was measured by reverse transcription real-time fluorescence quantification poly-merase chain reaction (RT-qPCR).The patients with pain after 3-month follow up served as herpes zoster neuralgia (PHN group) and those with pain disappearance served as the cure group (RC group).The expres-sion levels of miR-155-5p were compared between the HZN group and HA group and between the PHN group and RC group.The area under receiver operating characteristic (ROC) curve (AUC) and 95% confidence in-terval (CI) were calculated for evaluating the efficiency of miR-155-5p in predicting the chronicity of HZN. Results Compared with the HA group,the expression level of miR-155-5p in the HZN group was significant-ly up-regulated,and the difference was statistically significant (P<0.05);compare with the RC group,the ex-pression level of serum miR-155-5p in the PHN group was significantly up-regulated,and the difference was statistically significant (P<0.05);AUC of miR-155-5p for predicting the chronicity of HZN was 0.878 (95%CI:0.808-0.948).Conclusion The expression level of serum miR-155-5p in herpes zoster period of the pa-tients with PHN is significantly up-regulated compared with the cure patients and miR-155-5p could serve as an important predictive indicator of HZN chronicity.

MiR-155-5pherpes zoster neuralgiachronicityforewarning effect

沈倩倩、王波、杜忠举、夏菊荣

展开 >

杭州市第三人民医院皮肤外科 杭州 310009

杭州市第三人民医院麻醉科,杭州 310009

miR-155-5p 带状疱疹性神经痛 慢性化 预警作用

浙江省自然科学基金杭州区域创新发展联合基金资助项目浙江省医药卫生科技计划项目

LHZY24H0900012024KY201

2024

重庆医学
重庆市卫生信息中心,重庆市医学会

重庆医学

CSTPCD
影响因子:1.797
ISSN:1671-8348
年,卷(期):2024.53(16)