Predictive value of lncRNA CHRF and NT-proBNP in complicating cerebral-cardiac syndrome in patients with acute ischemic stroke
Objective To investigate the predictive value of long non-coding RNA cardiac hypertrophy-related factor (lncRNA CHRF) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in complicating cerebral-cardiac syndrome (CCS) in the patients with acute ischemic stroke (AIS).Methods A total of 121 patients with AIS admitted and treated in this hospital from November 2021 to October 2023 were selected as the study subjects and divided into the CCS group (n=49) and non-CCS group (n=72) according to whether or not complicating CCS during hospitalization.The clinical indicators,lncRNA CHRF and NT-proBNP levels were compared between the two groups.Pearson was adopted to conduct the correlation analysis.The multiva-riate Logistic regression was used to analyze the independent influencing factors of AIS complicating CCS.The receiver operating characteristic (ROC) curve was drawn to analyze the predictive value of the related indica-tors.Results The age,serum creatinine,hypersensitive C reactive protein (hs-CRP),creatine kinase isoenzymes MB (CK-MB),cardiac troponin I (cTnI),lncRNA CHRF and NT-proBNP in the CCS group were higher than those in the non-CCS group (P<0.05),and left ventricular ejection fraction (LVEF) was lower than that in the non-CCS group (P<0.05).The correlation analysis showed that lncRNA CHRF in the pa-tients with AIS complicating CCS was positively correlated with NT-proBNP (P=0.040).The lncRNA CHRF and NT-proBNP levels were positively correlated with CK-MB,cTnI and hs-CRP levels (P<0.05),and negatively correlated with LVEF (P<0.05).The multivariate logistic regression analysis showed that the decrease of LVEF,increase of lncRNA CHRF and NT-proBNP were the independent risk factors for complica-ting CCS in the patients with AIS (P<0.05).The ROC curve analysis showed that the area under the curve (AUC) of lncRNA CHRF and NT-proBNP alone and combination were 0.673,0.711 and 0.850 respectively. Conclusion The lncRNA CHRF and NT-proBNP levels are significantly increased in the patients with AIS complicating CCS,and their combined detection has high predictive value.
long non-coding RNA cardiac hypertrophy-related factorsN-terminal pro-B-type natriuretic peptidestrokecerebral-cardiac syndrome
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