Causal association between 4 kinds of lipid ingredients and gout:a Mendelian randomization study
Objective To investigate the causal association between four kinds of lipid components[to-tal cholesterol(TC),triglyceride(TG),high density lipoprotein-cholesterol(HDL-C),low density lipopro-tein-cholesterol(HDL-C)]and gout by using the two-sample Mendelian randomization analysis method.Methods The pooled data with a large sample of whole gene association studies were utilized to study the summarized data.The genetic loci closely related to four lipid components were selected as the instrumental variables.The inverse variance weighting method(IVW)was used as the main method,and weighted median(WME),MR-Egger regression,simple model method and weighted model method as the supplement,the data conducted the two samples MR analysis.The causal association among 4 kinds of lipid components with gout was evaluated by odds ratios(OR)value.The three methods of heterogeneity tests,pleiotropy tests and sensi-tivity analysis were used to assess the stability and reliability of the results.Results Hypertriglyceridemia could increase the risk of developing gout(OR=1.85,95％CI:1.29-2.66,P＜0.01).However TC(OR=1.12,95％CI:0.78-1.62,P=0.553),HDL-C(OR=0.76,95％CI:0.52-1.11,P=0.156)and LDL-C(OR=1.25,95％CI:0.95-1.63,P=0.105)had no significant causal association with the risk of developing gout.The heterogeneity test results of IVW method and MR-Egger regression showed that there was no het-erogeneity and the MR-Egger regression intercept test showed no pleiotropy.The test result of MR-Egger re-gression intercept term method showed that there was no gene pleiotropy.The Leave-one-out analysis did not find the non-specific single nucleotide polymorphisms(SNP)locus.Conclusion There may be a positive caus-al association between elevated TC and gout,suggesting that the population with hypertriglyceridemia should actively detect and pay attention to prevent the onset of gout.
万方数据
维普
