重庆医学2024,Vol.53Issue(17) :2631-2636.DOI:10.3969/j.issn.1671-8348.2024.17.014

基于限制性立方样条模型分析BMI与肛瘘间的剂量-反应关系

Analysis of dose and response relationship between body mass index and anal fistula based on restricted cubic spline model

叶桑瑜 黄子宸 郑丽华
重庆医学2024,Vol.53Issue(17) :2631-2636.DOI:10.3969/j.issn.1671-8348.2024.17.014

基于限制性立方样条模型分析BMI与肛瘘间的剂量-反应关系

Analysis of dose and response relationship between body mass index and anal fistula based on restricted cubic spline model

叶桑瑜 1黄子宸 1郑丽华2
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作者信息

  • 1. 北京中医药大学研究生院,北京 100029
  • 2. 中日友好医院肛肠二部,北京 100029
  • 折叠

摘要

目的 基于横断面调查的结果,分析BMI与肛瘘发生的关系.方法 对2022年3月至2023年11月在中日友好医院肛肠科就诊的545例肛瘘患者临床资料进行分析.根据BMI将患者分为4组:偏瘦(BMI<18.5 kg/m2)、正常(BMI 18.5~<24.0 kg/m2)、超重(BMI 24.0~<28.0 kg/m2)和肥胖(BMI≥28.0 kg/m2).logistic回归分析肛瘘发生的影响因素.结合限制性立方样条(RCS)模型分析BMI与肛瘘发生风险的剂量-反应关系.结果 logistic回归分析结果表明肥胖是肛瘘发生的危险因素(OR=2.08,95%CI:1.08~3.99,P=0.028).结合RCS分析结果表明,BMI与肛瘘发生风险存在"J"形趋势.此外,吸烟可增加肥胖人群肛瘘发生风险.结论 超重和肥胖是发生肛瘘的危险因素,建议易感人群合理控制体重,预防肛瘘发生.

Abstract

Objective To analyze the relationship between the body mass index(BMI)and anal fistula occurrence based on the results of cross-sectional survey.Methods The clinical data of 545 patients with a-nal fistula visiting in the proctology department of this hospital from March 2022 to November 2023 were ana-lyzed.The patients were divided into 4 groups based on BMI:skinny group(BMI<18.5 kg/m2),normal group(BMI 18.5-<24.0 kg/m2),overweight group(BMI 24.0-<28.0 kg/m2)and obese group(BMI ≥28.0 kg/m2).The logistic regression was used to analyze the influencing factors of fistula occurrence.The dose-response relationship between BMI and the occurrence risk of anal fistula was analyzed by combining with the restricted cubic spline(RCS)model.Results The logistic regression analysis results showed that obese was the risk factor of anal fistula occurrence(OR=2.08,95%CI:1.08-3.99,P=0.028).The combining RCS a-nalysis results showed that there was a"J"shaped trend between the BMI and the risk of anal fistula.In addi-tion,smoking could increase the risk of anal fistula occurrence in obese population.Conclusion Overweight and obesity are the risk factors for anal fistula occurrence.It is suggested that the susceptible population should control their body weight reasonably to prevent the occurrence of anal fistula.

关键词

肛瘘/体重指数/超重/肥胖

Key words

anal fistula/body mass index/overweight/obesity

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出版年

2024
重庆医学
重庆市卫生信息中心,重庆市医学会

重庆医学

CSTPCD
影响因子:1.797
ISSN:1671-8348
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