晚期早产适于胎龄儿宫外生长迟缓的危险因素分析

Analysis on risk factors of extrauterine growth retardation for late preterm infants appropriate for gestational age

王永明 ¹许梅 ¹马海佳 ¹李虹 ¹吴路江 ¹朱雪琴 ¹马利勇 ¹吴梦思 ¹薛三相 ¹罗靖侠¹

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作者信息

1. 银川市妇幼保健院新生儿科,银川 750000
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摘要

目的分析晚期早产儿适于胎龄儿宫外生长迟缓(EUGR)的危险因素.方法回顾性分析2016年1月至2022年6月于该院分娩收住新生儿科的1 402例早产适于胎龄儿临床资料,依据芬顿(Fenton)早产儿生长曲线将出院时体重是否低于同期同胎龄生长曲线第10百分位分为EUGR组(n=244)和非EUGR组(n=1 158).收集两组早产儿及母亲临床资料,分析早产儿发生EUGR的危险因素.结果 1 402例早产适于胎龄儿中发生EUGR 244例,EUGR发生率为17.4％.不同胎龄早产儿EUGR发生率比较,差异无统计学意义(P＞0.05).不同出生体重早产儿EUGR发生率比较,差异有统计学意义(P＜0.05).logistic回归分析显示,男性(OR=1.694,95％CI:1.144～2.507)、出生体重低(OR=0.989,95％CI:0.988～0.991)、喂养不耐受(OR=2.719,95％CI:1.234～5.990)、孕周短(OR=0.146,95％CI:0.103～0.207)、住院时间延长(OR=1.073,95％CI:1.031～1.117)为晚期早产适于胎龄儿出院时发生EUGR的危险因素(P＜0.05).亚组分析显示,男性、出生体重低、喂养不耐受、住院时间长为34～＜36周早产适于胎龄儿出院时发生EUGR的危险因素(P＜0.05),出生体重低、喂养不耐受只影响胎龄≥36周早产儿(P＜0.05).结论加强孕期保健、生后积极营养支持可降低晚期早产儿EUGR的发生风险.

Abstract

Objective To analyze the risk factors for extrauterine growth retardation(EUGR)in late preterm infants appropriate for gestational age.Methods The clinical data in 1 402 preterm infants appropri-ate for gestational age delivered and hospitalized in this hospital from January 2016 to June 2022 were analyzed retrospectively.They were divided into the EUGR group(n=244)and the non-EUGR group(n=1 158)ac-cording to whether or not the body weight at discharge was below the 10th percentile of the growth curve for the same gestational age at the same period based on the Fenton's preterm growth curve.The clinical data of preterm infants and mothers of the two groups were collected.The risk factors for EUGR occurrence in pre-mature infants were analyzed.Results Among 1 402 preterm infants appropriate for gestational age,EUGR occurred in 244 cases with the EUGR incidence rate of 17.4％.The EUGR incidence rate had no statistical difference among the different fetal ages of premature infants(P＞0.05).The EUGR incidence rate had sta-tistical difference among different birth weights of premature infants(P＜0.05).The logistic regression anal-ysis showed that male(OR=1.694,95％CI:1.144-2.507),low birth weight(OR=0.989,95％CI:0.988-0.991),feeding intolerance(OR=2.719,95％CI:1.234-5.990),short gestational weeks(OR=0.146,95％CI:0.103-0.207)and hospitalization duration extension(OR=1.073,95％CI:1.031-1.117)were the risk factors for EUGR occurrence in late premature infants appropriate for gestational age in discharge.The sub-group analysis showed that male,low birth weight,feeding intolerance and hospitalization duration extension were the risk factors for EUGR occurrence in the preterm infants with gestational ages of 34-＜36 weeks(P＜0.05).Low birth weight and feeding intolerance only affected the preterm infants≥36 weeks of gesta-tional age(P＜0.05).Conclusion Strengthening the pregnant duration health care and active nutritional sup-port after birth may reduce the risk of EUGR occurrence in late premature infants.

关键词

新生儿/晚期早产儿/适于胎龄儿/宫外生长迟缓/危险因素

Key words

newborn/late premature infants/infants appropriate for gestational age/extrauterine growth retardation/risk factor

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基金项目

宁夏自然科学基金项目(2022AAC03747)

出版年

2024

重庆医学

重庆市卫生信息中心,重庆市医学会

重庆医学

CSTPCD

影响因子：1.797

ISSN：1671-8348

参考文献量10

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