Analysis on clinical features and prognosis of patients with uterine corpus rhabdomyosarcoma base on SEER database
Objective To investigate the clinical pathological characteristics,treatment methods and prognosis of the patients with uterine corpus rhabdomyosarcoma(UcRMS).Methods The data from 237 pa-tients with UcRMS during 2000-2020 were retrospectively collected from the Surveillance,Epidemiology and End Results(SEER)database.The descriptive statistical method was employed to conduct the descriptive a-nalysis on clinicopathological characteristics and prognosis of UcRMS patients.The Kaplan-Meier method was adopted to conduct the survival analysis on the patients with different pathological types and treatment meth-ods,and draw the survival curve.The Log-rank test was employed to compare the survival analyses.The uni-variate and multivariate Cox regression were performed to analyze the independent factors affecting the prog-nosis of UcRMS patients.Results Among histologically confirmed cases,the most common type was embry-onic type(44 cases,18.6％)and followed by the pleomorphic type(35 cases,14.8％).In terms of treatment,21 cases(8.9％)received the surgery combined with chemotherapy and radiotherapy(surgery+chemotherapy+radiotherapy).75 cases(31.6％)received the surgery+chemotherapy,and 23 cases(9.7％)received the sur-gery+radiotherapy.The median overall survival(OS)time in the cohorts was 13 months,the median cancer-related survival(CSS)was 14 months,the 5-year OS rate and CSS rate were only 16％.The OS rate and CSS rate for embryonic type RMS were significantly better than those for the undefined and other pathological types,with statistically significant differences(P＜0.001).In terms of treatment,the OS rate and CSS rate in the surgery+chemotherapy+radiotherapy group were superior to those in the surgery+chemotherapy group and surgery+radiotherapy group,with statistically significant differences(P=0.011,P=0.012).The histological type,stage,surgery and chemotherapy were the factors affecting the OS time and CSS time of the patients(P＜0.05,P＜0.001).Conclusion The prognosis of embryonic type UcRMS is better than that of other histological types,but the overall prognosis is still poor,the 5-year survival rate is less than 20％.The histological type,stage,surgery and chemotherapy are the important influencing factors of prognosis,and the surgery+chemotherapy+radiotherapy could improve the prognosis of UcRMS patients.
rhabdomyosarcomauterine corpus rhabdomyosarcomaprognosisSEER database
万方数据
维普
