Research progress on pyroptosis in sepsis-associated encephalopathy
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infec-tion.Sepsis-associated encephalopathy(SAE)is one of the common complications of sepsis patients,which can be seen in 70％of sepsis patients,mainly manifested by sepsis-related cognitive dysfunction,and its pathogen-esis is complex,mainly including mitochondrial dysfunction,oxidative stress,neuroinflammation,autophagy,etc.Pyroptosis is a special type of programmed cell death that is involved in the regulation of inflammation and immune responses.Neuronal pyroptosis plays an important role in the pathogenesis of SAE.This paper re-views the pathologic mechanism,physiological mechanism,related signaling pathways and potential molecular regulatory mechanisms of neurons pyroptosis in SAE in order to provide the new ideas for the prevention and treatment of SAE.
万方数据
维普
