With the improvement of living standards,at least a quarter of the global population has non-alcoholic fatty liver disease(NAFLD),which is considered to be an important cause of the increased incidence of hepatocellular carcinoma(HCC)in recent years.Finding effective means for disease prevention and/or treatment largely relies on deep understanding of the mechanisms of NAFLD to HCC,which needs to con-struct the stable experimental models to simulate the entire process of disease progression in human NAFLD-HCC.This paper summarizes the animal models which are currently used to study NAFLD-HCC and their ad-vantages and disadvantages,in order to provide a basis for the selection of animal models and accelerate the transition from basic study to clinical study.
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