Study on correlation between vitamin D level and antiphospholipid antibody level in patients with recurrent miscarriage
Objective To explore the correlation between vitamin D and antiphospholipid antibody(APLa)level in the patients with recurrent spontaneous abortion(RSA).Methods A total of 157 patients with RSA visiting the RSA outpatient department of RSA of Hangzhou Municipal First People's Hospital from January 2022 to April 2023 were selected by the prospective clinical study as the study subjects.Among them,34 RSA cases of vitamin D deficiency complicating APLa abnormality(the study group)conducted the vitamin D supplement intervention and their vitamin D and APLa levels were dynamically monitored;27 RSA patients with vitamin D deficiency and APLa abnormality without vitamin D supplement intervention before intervention or at the same time visiting the department of non-RSA outpatient of this hospital served as the control group.The general data and the relationship between vitamin D and APLa level were compared be-tween the two groups.The pregnant outcomes in the two groups were analyzed.Results There were no differences in the general data such as age and BMI between the two groups(P＞0.05).In the study group,the vitamin D was negatively correlated with the APLa level(P＜0.001);after treatment,the vitamin D level was significantly increased and the APLa level was significantly decreased(P＜0.001).The adverse pregnan-cy outcomes had statistical difference between the two groups(P=0.043).Conclusion Among the patients with RSA,the vitamin D may be negatively correlated with the APLa level.Monitoring and evaluating the vi-tamin D and APLa levels,and adopting the vitamin D intervention before pregnancy as early as possible could prevent the occurrence risk of adverse pregnant outcomes in RSA,thus improve the pregnant outcome.
万方数据
维普
