Analysis on correlation between cardiac functional changes and coronary artery lesions in Kawasaki disease in children
Objective To investigate the correlation between the cardiac function change and coronary artery lesions(CAL)in acute stage and convalescent stage of children patients with Kawasaki disease.Meth-ods A total of 74 children patients with typical Kawasaki disease visiting to this hospital from June 2021 to December 2023 were selected as the study subjects.All study subjects conducted the echocardiographic exami-nation after admission.The patients were divided into the non-CAL group(CAL-group,n=44)and compli-cating CAL group(CAL+group,n=30)according to whether or not coronary artery having dilation.After 2-month treatment,the CAL+group was divided into the CAL+recovery group(n=17)and CAL+persistent dilation group(n=13).The differences in the ratio of interventricular septal thickness at end-diastole to left ventricular posterior wall thickness(IVST/LVPWT),ratio of aortic root diameter to main pulmonary artery diameter(AORD/MPAD),ratio of coronary artery diameter to aortic root,ratio of coronary artery diameter to body surface area,maximum aortic to pulmonary pressure ratio,percentage of left ventricular brachyaxis shortening and ejection fraction(EF)were compared among 3 groups.Results Compared with the CAL-group and CAL+recovery group,IVST/LVPWT in the acute stage and 1 month of clinical recovery in the CAL1 persistent dilation group was significantly increased(P＜0.05).Compared with the CAL-group and CAL1 persistent dilation group,AORD/MPAD in the acute stage and clinical recovery stage in the CAL+re-covery group was smaller(P＜0.05).Compared with the CAL-group,AORD/MPAD in the clinical recovery stage in the CAL+persistent dilation group was smaller(P＜0.05).Compared with the CAL+persistent dila-tion group,the ratio of left and right coronary artery internal diameter to aortic root and ratio of left and right coronary artery to body surface area in the acute stage,clinical recovery stage and in 1,2 months after clinical recovery were greater,and the differences were statistically significant(P＜0.05).In the clinical symptoms remission stage,compared with the CAL-group,the maximum aortic artery to pulmonary artery pressure ra-tio in the CAL+persistent dilation group was lower,and the difference was statistically significant(P＜0.05).EF and FS in the acute stage,clinical symptoms remission stage and in 1,2 months after clinical recov-ery had no statistical differences among the three groups(P＞0.05).Conclusion The cardiac function exami-nation in children patients with Kawasaki disease could serve as the evaluation indicator for the prognosis of CAL.
万方数据
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