首页|疼痛的神经环路研究相关技术应用进展

疼痛的神经环路研究相关技术应用进展

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疼痛是一种与真实或潜在的组织损伤相关的不适感和情感体验,或类似相关感觉的体验。然而,疼痛远非单纯的生理感觉,其背后涉及复杂的情感和神经调节机制。疼痛神经环路为复杂生物学系统,涵盖末梢神经元至大脑皮质、丘脑、杏仁核、脊髓背角等中枢神经系统的多层次结构,参与感知、传导和调控疼痛信号,牵涉多种分子和细胞水平的相互作用,构建全面的疼痛感知过程。近年来,疼痛神经环路研究领域运用多种科学技术工具,为深入理解和治疗疼痛提供了理论和技术支持。该文通过对不同技术在疼痛神经环路方面研究中的应用进行梳理,旨在为相关领域的学者提供全面的研究现状,为临床疼痛研究及治疗提供新的思路。
Advances in application of techniques related to study of neural circuits in pain
Pain is an uncomfortable and emotional experience associated with,or similar to,real or po-tential tissue damage.However,far from being a purely physiological sensation,pain involves complex emo-tional and neuromodulatory mechanisms.The pain neural circuit is a complex biological system,covering the multi-level structure of the central nervous system from peripheral neurons to the cerebral cortex,thalamus,a-mygdala and dorsal horn of the spinal cord,participating in the perception,conduction,and regulation of pain signals,involves multiple molecular and cellular interactions to build a comprehensive pain perception process.In recent years,the field of pain neural circuit research has used a variety of scientific and technological tools to provide the theoretical and technical support for the in-depth understanding and treatment of pain.This article aims to provide a comprehensive research status quo for the scholars in related fields and new ideas for clinical pain research and treatment by combing the application of different technologies in the study of pain neural circuits.

painneural circuitsregulatory mechanismstechnology applicationreview

王建业、边艳琴、向峥、裴少强、程意伟、沈军、肖涟波

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上海中医药大学附属光华医院,上海 200052

上海市中医药研究院中西医结合关节炎研究所,上海 200052

疼痛 神经环路 调节机制 技术应用 综述

2024

重庆医学
重庆市卫生信息中心,重庆市医学会

重庆医学

CSTPCD
影响因子:1.797
ISSN:1671-8348
年,卷(期):2024.53(23)