Predictive value of plasma ApoE and retinol binding protein changes after PCI for adverse cardiovascular events in patients with acute myocardial infarction
Objective To analyze the predictive value of plasma apolipoprotein E(ApoE)and retinol-binding protein(RBP)changes on adverse cardiovascular events(MACE)after percutaneous coronary inter-vention(PCI)in the patients with acute myocardial infarction(AMI).Methods A total of 85 patients with AMI undergoing PCI in the Second Affiliated Hospital of Xi'an Jiaotong University from April 2021 to De-cember 2022 were selected as the study subjects.After PCI,the enzyme-linked immunosorbent assay was used to detect the RBP level and the latex-enhanced immunoturbidimetry was used to detect the ApoE level.The incidence situation of MACE in the patients with 1-year follow-up was followed up by telephone or on-site method.The patients were divided into the two groups,the patients with MACE occurrence were included in the occurrence group and those without MACE occurrence were in the non-occurrence group.The basic data were compared between the two groups.The influencing factors of ApoE combined with RBP in predicting the occurrence of MACE after PCI in AMI patients were analyzed and the efficiency of ApoE and RBP levels in predicting MACE occurrence after PCI in AMI patients was analyzed.Results Among 85 patients with AMI undergoing PCI,14 cases(16.47％)developed MACE,including 6 cases of revascularization,3 cases of severe arrhythmia and 5 cases of severe heart failure.There were 71 cases(83.53％)of non-MACE occurrence.The level of LVEF in the occurrence group was lower than that in the non-occurrence group,and the ApoE and RBP levels and Killip grade Ⅲ-Ⅳ in the occurrence group were higher than those in the non-occurrence group(P＜0.05).The logistic regression analysis results showed that the increase of ApoE and RBP levels and Killip grade Ⅲ-Ⅳ were the risk factors for predicting the MACE occurrence after PCI in AMI patients,while the LVEF increase was the protective factor for the MACE occurrence after PCI in AMI patients(P＜0.05).The receiver operating characteristic(ROC)curve analysis results showed that the sensitivities of LVEF,ApoE,RBP and Killip grade alone and combined prediction for the MACE occurrence after PCI in AMI patients were 71.43％,78.57％,78.57％,71.43％and 92.86％,respectively.The specificities were 74.65％,81.69％,77.46％,70.42％and 91.55％,respectively.The combination detection had the higher predictive val-ue.Conclusion The ApoE and RBP levels are the influencing factors for the MACE occurrence after PCI in AMI patients,and the LVEF and Killip grade combination could better predict the MACE occurrence after PCI in AMI patients.
万方数据
维普
