摘要
目的 筛选辅助检查儿童川崎病(KD)的生物学标志物.方法 选取2022年1月至2023年12月于该院住院的208例初发KD患儿作为KD组,另选取于该院健康查体的208例健康儿童作为对照组,检测两组血清C反应蛋白(CRP)、WBC、PLT、红细胞沉降率(ESR)、降钙素原(PCT)、抗链球菌溶血素O(ASO)、白细胞介素-6(IL-6)、免疫球蛋白(Ig)G、IgA、IgM、IgE、补体C3、补体C4、血清铁蛋白(Fer)水平,并用受试者工作特征(ROC)曲线评价各生物学标志物对KD诊断的价值.结果 KD组CRP、WBC、PLT、ESR、PCT、IL-6、IgM、补体C4、Fer水平高于对照组,差异有统计学意义(P＜0.05).ROC曲线显示,CRP、WBC、ESR、PCT、IL-6曲线下面积(AUC)均＞0.9,其中CRP的AUC为1.000,以2.25 ng/L为截断值时的灵敏度为100.0％,特异度为100.0％;IL-6的AUC为0.998,以6.595 mg/L为截断值时的灵敏度为97.1％,特异度为99.0％;ESR的AUC为0.987,以18.50 mm/h为截断值时的灵敏度为96.0％,特异度为99.0％.结论 CRP、IL-6和ESR具有较高的KD诊断价值.
Abstract
Objective To screen the biological markers in the assisted detection of childhood Kawasaki disease(KD).Methods A total of 208 children inpatients initially diagnosed as KD in this hospital from Janu-ary 2022 to December 2023 were selected as the KD group,and 208 healthy children undergoing physical ex-amination in this hospital were selected as the control group.Serum C reactive protein(CRP),white blood cells(WBC),platelets(PLT),erythrocyte sedimentation rate(ESR),procalcitonin(PCT),antistreptolysin O(ASO),interleukin-6(IL-6),immunoglobulin IgG,IgA,IgM,IgE,complement C3,C4 and serum ferritin(Fer)in the two groups were detected,and the receiver operating characteristic(ROC)curve was used to e-valuate the value of the various biological indexes for diagnosing KD.Results The levels of CRP,WBC,PLT,ESR,IgM,complement C4,Fer,PCT and IL-6 in the KD group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The ROC curve showed that the areas under the curves(AUC)of CRP,WBC,ESR,PCT and IL-6 all were＞0.9,in which,AUC of CRP was 1.000,when 2.25 ng/L was the cut-off value,the sensitivity and specificity were 100.0％.AUC of IL-6 was 0.998,when 6.595 mg/L was the cut-off value,the sensitivity was 97.1％and the specificity was 99.0％.AUC of ESR was 0.987,when 18.50 mm/h was the cut-off value,the sensitivity was 96.0％and the specificity was 99.0％.Conclusion CRP,IL-6 and ESR have the higher diagnostic value for KD.
维普
万方数据