Risk of atrial fibrillation in different age groups on onset of new-onset acute myocardial infarction
Objective To investigate whether suffering from atrial fibrillation in different ages of people increasing the onset risk of new-onset acute myocardial infarction(AMI).Methods A prospective cohort study was conducted to select 96 624 Kailuan Group employees undergoing the health examination from June 2006 to October 2007 for including the study.The participants were followed up once a year,and the last fol-low-up date was December 31,2020,with a median follow-up of 14.01 years,and the endpoint event was new-onset AMI.The participants were divided into two age groups according to the age ≥60 years and the age＜60 years old,and divided into the atrial fibrillation group and non-atrial fibrillation group according to whether they had atrial fibrillation.The epidemiological investigation and anthropometric measurements were carried out on the participates.Whether atrial fibrillation was correlated to the onset of new-onset AMI in different age groups conducted the statistical analysis.Results Among the total participants,there were 411 cases in the atrial fibrillation group and 96 213 cases in the non-atrial fibrillation group.Among the participants＜60 years old,there were 121 cases in the atrial fibrillation group and 75 151 cases in the non-atrial fibrillation group.Among the participants ≥60 years old,there were 290 cases in the atrial fibrillation group and 21 062 cases in the non-atrial fibrillation group.In the total participants,the cumulative incidence rate of AMI in the atrial fibrillation group was higher than that in the non-atrial fibrillation group(5.68％vs.1.92％),and the difference was statistically significant(P＜0.05).In the participants＜60 years old,the cumulative incidence rate of AMI in the atrial fibrillation group was higher than that in the non-atrial fibrillation group(7.40％vs.1.43％),and the difference was statistically significant(P＜0.05).In the participants 60 year old,the cu-mulative incidence rate of AMI had no statistical difference between the atrial fibrillation group and non-atrial fibrillation group(4.54％vs.3.87％,P=0.547).In the whole participants,atrial fibrillation was a risk factor for new-onset AMI(HR=1.877,95％CI:1.177-2.991,P=0.008),and there was an interaction between age and atrial fibrillation(P=0.016).In the age stratification analysis,atrial fibrillation was a risk factor for new-onset AMI in＜60-year-old population(HR=3.029,95％CI:1.508-6.082,P=0.002).Conclusion Atrial fibrillation is an independent risk factor for new-onset AMI,especially to young and middle-aged people(＜60 years old).
atrial fibrillationnew-onset acute myocardial infarctionrisk factorsepidemiologyrisk of onset
万方数据
维普
