Correlation between abnormal serum detection indicators of intestinal barrier function with metabolic diseases
Objective To explore the correlation between serum detection indicators abnormality of in-testinal barrier function with metabolic diseases.Methods A total of 26 838 individuals undergoing serum de-tection of intestinal barrier function in the physical examination center of this hospital from January 2020 to August 2023 were selected as the study subjects and grouped based on whether D-lactic acid(DLC),bacterial endotoxin(BT)and diamine oxidase(DAO)were abnormal.Their clinical data of the patients with abnormal DLC,BT and DAO were collected,including the body weight,blood pressure[systolic blood pressure(SBP)and diastolic blood pressure(DBP)],fasting blood glucose(GLU),pulse rate,total bilirubin(TBIL),direct bilirubin(DBIL),indirect bilirubin(IBIL),total protein(TP),alanine aminotransferase(ALT),aspartate aminotransferase(AST),and human plasma protein phospholipase(Lp-PLA2),etc.;the incidence rate of fat-ty liver in the subjects with abnormal DLC,BT and DAO was statistically analyzed,and the correlation be-tween abnormal DLC,BT and DAO with the fatty liver occurrence was analyzed.Results Among the 26 838 individuals undergoing physical examination,there were 544 cases(2.03％)of abnormal DLC,927 cases(3.45％)of abnormal BT and 649 cases(2.42％)of abnormal DAO.In the populations with abnormal DLC,BT and DAO,the detection rate in the male patients was significantly higher than that in the females,moreo-ver which were often accompanied by obesity,increased blood pressure and elevated blood sugar.68.08％of the patients with abnormal BT had high SBP,51.02％of the patients had high DBP,and 40.72％of the pa-tients had high GLU.99.58％of patients with abnormal DLC had abnormal IBIL.The population with abnor-mal serum DLC,BT and DAO had the high incidence rate of fatty liver,which were 43.57％,44.77％and 38.83％,respectively.The Spearman's rank correlation analysis showed that the DLC,BT and DAO levels were correlated with the occurrence of fatty liver(P＜0.05).Conclusion The DLC,BT and DAO levels could early warn hypertension,diabetes and liver function damage caused by metabolic disorders,and predict the risk of fatty liver occurrence.
万方数据
维普
