Research progress of biological clock gene in acute inflammatory diseases
The circadian rhythm of the body is mainly regulated by the biological clock gene,which is the result of biological evolution and plays an important role in maintaining the normal function of the organ-ism.When the circadian rhythm is disturbed or disordered,it will produce adverse health consequences.The current researches find that circadian rhythm disorder mediated by biological clock gene plays an important regulatory role in the occurrence and development of acute inflammatory diseases,such as sepsis,ischemia-reperfusion injury and COVID-19.This paper reviews the research progress of biological clock gene in acute inflammatory diseases in recent years,and discusses the role of targeted biological clock gene in the treatment of inflammatory related diseases and the existing problems.
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